Najla’ Shakirah Ab Halim, Sheril June Ankasha, Aslah Nabilah Abdull Sukor, N. N. Mohamad Anuar, Norhazlina Abdul Wahab, Shahidee Zainal Abidin, A. Ugusman, Adila A. Hamid
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引用次数: 0
摘要
血管生成是一个受到严格调控的生理过程,其特点是新生血管的发育。由于血管生成失衡可能导致多种病理疾病,包括癌症、视网膜病变和关节炎,因此具有控制血管生成潜力的化合物将极具治疗价值。本研究对何首乌的抗血管生成作用进行了全面综述,同时还发现这种植物还具有其他药用价值,如抗氧化、抗炎、抗增殖和抗肿瘤等。因此,本研究系统地确定了报道何首乌抗血管生成作用的证据。研究人员在 PubMed、Ovid MEDLINE、Scopus 和 Web of Science 四个电子数据库中搜索了相关文章。根据预先设定的资格标准,确定了 50 篇相关文章,并选择和审查了 10 篇合格文章。结果表明,P. cuspidatum、P. barbatum、P. hydropiper 和 P. perfoliatum 四种蓼属植物主要通过抑制血管内皮生长因子信号通路而表现出抗血管生成活性。因此,这些何首乌物种有可能被开发为天然抗血管生成剂,用于预防和治疗与病理性血管生成有关的各种疾病。
Anti-Angiogenic Effect of Polygonum Species: A Comprehensive Review of Literature
Angiogenesis is a physiological, tightly regulated process which is characterized by the development of new blood vessels. Compounds with the potential to control angiogenesis would be highly valuable as therapeutics, as an imbalance in angiogenesis may lead to several pathological disorders, including cancer, retinopathy, and arthritis. In this study, the anti-angiogenic effect of Polygonum sp. has been comprehensively reviewed and this plant also has been known to possess other medicinal benefits such as antioxidative, anti-inflammatory, anti-proliferative, and anti-tumor agents. Hence, this study systematically identified the evidence reporting the anti-angiogenic effects of Polygonum sp. Four electronic databases, namely PubMed, Ovid MEDLINE, Scopus and Web of Science were searched for relevant articles. Based on the pre-set eligibility criteria, 50 relevant articles were identified, and ten qualified articles were selected and reviewed. It was demonstrated that four namely P. cuspidatum, P. barbatum, P. hydropiper, and P. perfoliatum showed anti-angiogenic activities mainly through inhibition of the vascular endothelial growth factor-signaling pathways. Therefore, these species Polygonum have the potential to be developed as natural anti-angiogenic agents for prevention and treatment of various diseases related to pathological angiogenesis.
期刊介绍:
Sains Malaysiana is a refereed journal committed to the advancement of scholarly knowledge and research findings of the several branches of science and technology. It contains articles on Earth Sciences, Health Sciences, Life Sciences, Mathematical Sciences and Physical Sciences. The journal publishes articles, reviews, and research notes whose content and approach are of interest to a wide range of scholars. Sains Malaysiana is published by the UKM Press an its autonomous Editorial Board are drawn from the Faculty of Science and Technology, Universiti Kebangsaan Malaysia. In addition, distinguished scholars from local and foreign universities are appointed to serve as advisory board members and referees.