卵巢内注射自体富血小板血浆对卵巢储备功能低下妇女的疗效:系统回顾和荟萃分析

IF 0.5 Q4 REPRODUCTIVE BIOLOGY
Yasmin Sabina Sa’diah, Agung Dewanto, L. A. Chandra
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引用次数: 0

摘要

对评估自体富血小板血浆(PRP)对卵巢储备功能低下疗效的实验研究中最可靠的数据进行系统检查和荟萃分析。 我们利用相关检索词在PubMed、Cochrane和谷歌学术等电子数据库中进行了全面检索。我们纳入了将卵巢储备功能低下的不孕妇女分配到实验研究中的研究。在向卵巢注射 PRP 之前和之后测量了卵巢储备参数。我们检索了每项研究的数据,随后进行了汇编。 在收集和审查的 301 篇文章中,最终有 6 项研究被纳入荟萃分析。注射 PRP 后,不孕妇女的抗苗勒氏管激素(AMH)水平出现了非显著性升高(MD=0.10;95% CI -0.04,0.23),前卵泡计数(AFC)显著升高(MD=1.88;95% CI 0.47,3.29),而促卵泡激素(FSH)水平则出现了非显著性降低(MD=-0.22;95% CI -8.32,7.87)。 自体 PRP 可增加 AFC,但不会增加 AMH。虽然自体血浆蛋白对提高卵巢储备功能(AFC)有益,但仍需要进一步的研究和有力的证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efficacy of intraovarian autologous platelet-rich plasma administration in women with low ovarian reserve: A systematic review and meta-analysis
To conduct a systematic examination and meta-analysis of the most reliable data from experimental studies evaluating the efficacy of autologous platelet-rich plasma (PRP) on low ovarian reserve. A comprehensive search was performed utilizing pertinent search terms across electronic databases, including PubMed, Cochrane, and Google Scholar. We included studies that assigned infertile women with low ovarian reserve in experimental studies. Ovarian reserve parameters were measured before and after PRP injection into ovaries. The data of each study was retrieved and subsequently compiled. Of 301 articles collected and reviewed, six studies were finally included in the meta-analysis. Following PRP injection, infertile women showed a non-significant increase in anti-Mullerian hormone (AMH) level (MD=0.10; 95% CI -0.04, 0.23), a significant increase in antral follicular count (AFC) (MD=1.88; 95% CI 0.47, 3.29), and a non-significant reduction in follicle-stimulating hormone (FSH) level (MD=-0.22; 95% CI -8.32, 7.87). Autologous PRP may increase AFC, but not AMH. Although it is found beneficial in enhancing ovarian reserve (AFC), further research with strong evidence is still required.
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来源期刊
Asian Pacific Journal of Reproduction
Asian Pacific Journal of Reproduction Veterinary-Veterinary (all)
CiteScore
1.70
自引率
0.00%
发文量
588
审稿时长
9 weeks
期刊介绍: The journal will cover technical and clinical studies related to health, ethical and social issues in field of Gynecology and Obstetrics. Articles with clinical interest and implications will be given preference.
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