异丙肾上腺素对大鼠腮腺唾液腺1-酰基-sn-甘油-3-磷酸和1-酰基-sn-甘油-3-磷胆碱酰基转移酶的诱导作用。

Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology Pub Date : 1988-01-01

K Yashiro, Y Kameyama, M Mizuno, Y Yokota

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引用次数: 0

摘要

1. 在大鼠腮腺中，长期给药异丙肾上腺素导致亚油酸显著升高，磷脂酰胆碱sn-2位点花生四烯酸显著降低。2. 异丙肾上腺素处理大鼠腮腺微粒体中1-酰基- n-甘油酸-3-磷酸和1-酰基- n-甘油酸-3-磷胆碱酰基转移酶活性分别提高3-8倍和2倍。3.此外，这两种酶对各种酰基辅酶a的特异性也随着异丙肾上腺素的施用而改变。4. 磷脂酰胆碱sn-2位不饱和脂肪酸组成的改变至少部分是由于溶血磷脂酰基转移酶的活性和底物特异性的改变。

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Inducing effects of chronic administration of isoproterenol on 1-acyl-sn-glycero-3-phosphate and 1-acyl-sn-glycero-3-phosphocholine acyltransferases in rat parotid salivary gland.

1. In rat parotid gland, chronic administration of isoproterenol caused significant increase of linoleic acid and decrease of arachidonic acid at the sn-2 position of phosphatidylcholine. 2. The activities of 1-acyl-sn-glycero-3-phosphate and 1-acyl-sn-glycero-3-phosphocholine acyltransferases were increased 3-8-fold and 2-fold, respectively, in the parotid gland microsomes of isoproterenol-treated rat. 3. Furthermore, the specificity of these two enzymes for various acyl-CoAs was also changed by administration of isoproterenol. 4. The alteration of unsaturated fatty acid composition at the sn-2 position of phosphatidylcholine was at least in part due to the change of activity and substrate specificity of lysophospholipid acyltransferases.

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Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology

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