Younghoon Park, Jaewoo Shin, Junwon Park, Jeongju Moon, Won Seok Chang, Kyungsik Eom
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Focused ultrasound as a novel noninvasive method for the delivery of gold nanoparticles to retinal ganglion cells
Delivery of gold nanoparticles (AuNPs) to retinal ganglion cells (RGC) is being explored as a potential treatment for various retinal diseases. The use of focused ultrasound with microbubbles (FUS) as non-invasive delivery method for metallic nanoparticles of various sizes and shapes has not been fully investigated. Here, we demonstrate the FUS-assisted delivery of AuNPs of varying size and shapes to RGC and confirmed by two-photon microscopic imaging of the injected AuNPs in the RGC layer.
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