Novel Chitosan Nanoparticles based 1,2,3-triazole moieties as potent drugs against multi-drug resistant bacteria

: Drug resistance is a major global problem leading to higher morbidity and mortality rates especially among hospitalized patients. Hence, in the present study, 1,2,3-Triazole-acetophnone molecular conjugates 3a-c were resynthesized and then used in nanoformulated composites ( 3a-cCNPs) using chitosan as a matrix to give nano compounds of particle sizes ranging from 20 to 40 nm. Antimicrobial activity of the synthesized compounds and the nanoformulated analogues against some multi-drug resistant microbes revealed that 3bCNPs was the most potent candidate due to its high efficiency against multi-drug resistant (MDR) microbes that reached complete microbial cells eradication after 4 hours. The synthesized nanoparticles