Revere the Exclusion Nature of the Human Body

Overusing artificial interventions such as intravenous infusion of antimicrobial agents or chemotherapy drugs can lead to adverse reactions (ADRs). The underlying biochemical mechanisms of these ADRs are widely studied but rarely from the evolutionary perspective. Extending the concept of evolution that man must adapt to nature to survive, we propose that medicine should adapt to the nature of the human body. It enables us to point out a mechanism that unnatural drugs entering the body in an unnatural way will trigger excessive free radicals to attack the body, which may be the common source of adverse reactions to infusion and chemotherapy. On the contrary, due to the long-term adaptation of the human body, intestinal digestion of herbal medicines is relatively less likely to stimulate excessive free radicals, and tea drinking is significantly beneficial to clearing excessive free radicals. Our research supports a shift towards an evolutionary-aware medicinal approach that aligns with human physiology to minimize ADRs. Further investigation is required to verify and incorporate this mechanism into clinical practice, which could significantly enhance treatment safety and effectiveness.