评估医护人员接种 COVID-19 疫苗后的抗体反应:土耳其一家三级医院的经验

Fatih Çubuk, Rukiye Aslan, M. Hasbek, Ayşe Hümeyra Taşkın Kafa
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引用次数: 0

摘要

研究目的本研究旨在探讨医护人员接种第二剂疫苗后的抗体反应中人口统计学特征与是否存在合并症之间的相关性。此外,还观察了参与者接种第三剂和第四剂疫苗的情况以及两剂疫苗对 COVID-19 所形成的抗体水平的保护作用。材料和方法:在接种第二剂 CoronaVac 疫苗后的第 30 天检测到 NCP 和 S 蛋白抗体水平的医务工作者,对其接种第三剂和第四剂疫苗以及 COVID-19 的情况进行跟踪调查。结果显示接种两剂疫苗后,女性体内的 S 抗体水平更高(P=0.001)。研究指出,吸烟对接种后的抗体反应有负面影响(p=0.008)。接种前接种过 COVID-19 疫苗的人在接种两剂疫苗后的 NCP 抗体水平更高(p=0.013)。参与者中有 152 人(97.4%)接种了第三剂疫苗,110 人(70.5%)接种了第四剂疫苗。结论女性、年轻人、非吸烟者和以前未感染过 SARS-CoV-2 的人在接种两剂灭活 CoronaVac® 疫苗探针后的抗体反应明显较高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of Antibody Response After COVID-19 Vaccination in Healthcare Workers: A Turkish Tertiary Hospital Experience
Objective: It was aimed to explore the correlation between demographic characteristics and the presence of comorbidity in the antibody response after the second dose of vaccination in healthcare workers in this study. In addition, the third and fourth dose approaches of the participants and the protection of the antibody levels formed by the two doses of vaccine against COVID-19 were examined observationally. Materials and Methods: Health workers, whose NCP and S protein antibody levels were detected on the 30th day after the second dose of the CoronaVac vaccine, were followed up in terms of being vaccinated for the third and fourth doses and having COVID-19. Results: Higher levels of S antibodies were detected in women after two doses of vaccination (p=0.001). It was pointed out that smoking has a negative effect on the antibody response after vaccination (p=0.008). People who had pre-vaccine COVID-19 had higher NCP antibody levels after two doses of vaccination (p=0.013). Of the participants, 152 (97.4%) were vaccinated with the third dose and 110 (70.5%) with the fourth dose. Conclusion: The antibody response after two doses of inactivated CoronaVac® vaccination probe is significantly higher in women, younger people, non-smokers, and people who have not been previously infected with the SARS-CoV-2.
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