治疗和预防动物维生素和微量元素缺乏症的药物技术研究和稳定性

T. Velesyk, O. O. Overchuk, V. Y. Chernega
{"title":"治疗和预防动物维生素和微量元素缺乏症的药物技术研究和稳定性","authors":"T. Velesyk, O. O. Overchuk, V. Y. Chernega","doi":"10.32718/ujvas7-1.13","DOIUrl":null,"url":null,"abstract":"The article presents the research results on the Development of manufacturing technology and the study of the stability of a solution for oral use based on carnitine hydrochloride, vitamins – E, B12, choline chloride, selenium, and zinc. “Devivit Carnitine” oral is used for the prevention of diseases of liver and muscle tissue metabolism in farm animals and poultry, nephrosis, myocarditis, prevention of stress (heat, transport, sound, food, post-vaccination, etc.), and prevention of vitamin and hypovitaminosis. When developing the drug technology, experimentally obtained pharmaco-technological properties of active substances and excipients were taken into account. The technological process of preparing an oral solution consists of four technological stages: preparation of canisters for filling, preparation of the solution, filling containers with medicine and packaging. The stability and shelf life of “Devivit Carnitine” (solution for oral use) in plastic canisters were determined. It was established that the drug sample in plastic canisters was stable, according to all quality control methods indicators, during the entire period of the study. The shelf life of the medicinal product with carnitine hydrochloride, vitamins E and B12, choline chloride, selenium, and zinc is 12 months. In the future, a study of preclinical data is planned to verify whether the drug does not reveal a particular hazard for animals based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenicity, and developmental toxicity.","PeriodicalId":231752,"journal":{"name":"Ukrainian Journal of Veterinary and Agricultural Sciences","volume":" 9","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Pharmaco-technological research and stability of the drug for the treat-ment and prevention of vitamin and trace element deficiency in animals\",\"authors\":\"T. Velesyk, O. O. Overchuk, V. Y. Chernega\",\"doi\":\"10.32718/ujvas7-1.13\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The article presents the research results on the Development of manufacturing technology and the study of the stability of a solution for oral use based on carnitine hydrochloride, vitamins – E, B12, choline chloride, selenium, and zinc. “Devivit Carnitine” oral is used for the prevention of diseases of liver and muscle tissue metabolism in farm animals and poultry, nephrosis, myocarditis, prevention of stress (heat, transport, sound, food, post-vaccination, etc.), and prevention of vitamin and hypovitaminosis. When developing the drug technology, experimentally obtained pharmaco-technological properties of active substances and excipients were taken into account. The technological process of preparing an oral solution consists of four technological stages: preparation of canisters for filling, preparation of the solution, filling containers with medicine and packaging. The stability and shelf life of “Devivit Carnitine” (solution for oral use) in plastic canisters were determined. It was established that the drug sample in plastic canisters was stable, according to all quality control methods indicators, during the entire period of the study. The shelf life of the medicinal product with carnitine hydrochloride, vitamins E and B12, choline chloride, selenium, and zinc is 12 months. In the future, a study of preclinical data is planned to verify whether the drug does not reveal a particular hazard for animals based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenicity, and developmental toxicity.\",\"PeriodicalId\":231752,\"journal\":{\"name\":\"Ukrainian Journal of Veterinary and Agricultural Sciences\",\"volume\":\" 9\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-03-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ukrainian Journal of Veterinary and Agricultural Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.32718/ujvas7-1.13\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ukrainian Journal of Veterinary and Agricultural Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32718/ujvas7-1.13","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

文章介绍了基于肉碱盐酸盐、维生素 E、B12、氯化胆碱、硒和锌的口服溶液的生产技术开发和稳定性研究成果。"Devivit Carnitine "口服液用于预防农场动物和家禽的肝脏和肌肉组织代谢疾病、肾病、心肌炎、预防应激(热、运输、声音、食物、接种疫苗后等)以及预防维生素和维生素缺乏症。在开发药物技术时,考虑了从实验中获得的活性物质和辅料的药物技术特性。配制口服溶液的技术过程包括四个技术阶段:准备灌装罐、配制溶液、向容器中灌装药物和包装。对塑料罐装 "Devivit Carnitine"(口服溶液)的稳定性和保质期进行了测定。结果表明,在整个研究期间,根据所有质量控制方法指标,塑料罐装药物样品是稳定的。含有盐酸肉碱、维生素 E 和 B12、氯化胆碱、硒和锌的药品保质期为 12 个月。今后,计划对临床前数据进行研究,以根据安全药理学、重复剂量毒性、遗传毒性、致癌 性和发育毒性等常规研究,验证该药物是否不会对动物造成特殊危害。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pharmaco-technological research and stability of the drug for the treat-ment and prevention of vitamin and trace element deficiency in animals
The article presents the research results on the Development of manufacturing technology and the study of the stability of a solution for oral use based on carnitine hydrochloride, vitamins – E, B12, choline chloride, selenium, and zinc. “Devivit Carnitine” oral is used for the prevention of diseases of liver and muscle tissue metabolism in farm animals and poultry, nephrosis, myocarditis, prevention of stress (heat, transport, sound, food, post-vaccination, etc.), and prevention of vitamin and hypovitaminosis. When developing the drug technology, experimentally obtained pharmaco-technological properties of active substances and excipients were taken into account. The technological process of preparing an oral solution consists of four technological stages: preparation of canisters for filling, preparation of the solution, filling containers with medicine and packaging. The stability and shelf life of “Devivit Carnitine” (solution for oral use) in plastic canisters were determined. It was established that the drug sample in plastic canisters was stable, according to all quality control methods indicators, during the entire period of the study. The shelf life of the medicinal product with carnitine hydrochloride, vitamins E and B12, choline chloride, selenium, and zinc is 12 months. In the future, a study of preclinical data is planned to verify whether the drug does not reveal a particular hazard for animals based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenicity, and developmental toxicity.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信