急性冠状动脉综合征患者的全身免疫炎症指数与中期死亡率之间的关系

Suleyman Akkaya, Umit Cakmak
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引用次数: 0

摘要

背景:免疫炎症已被研究为不同疾病的预后标志物。考虑到炎症在急性冠状动脉综合征(ACS)发病机制中的关键作用,预测 ACS 患者的预后至关重要。因此,我们评估了用全身免疫炎症指数(SII)测量的炎症与 ACS 患者中期死亡率之间的关系:这项单中心回顾性研究由 539 名年龄超过 18 岁的 ACS 患者组成(139 名不稳定型心绞痛 [USAP]、165 名非 ST 段抬高型心肌梗死 [NSTEMI] 和 235 名 ST 段抬高型心肌梗死 [STEMI])。研究人员采用描述性统计和多变量回归法来检验临床和实验室参数特征与 12 个月死亡率之间的关系:患者的中位年龄为 58 岁(50-67 岁),73.1% 的患者为男性。共有20名患者在发生急性心肌梗死后的12个月内死亡。STEMI 患者的中位 SII 水平最高 [1301.96 (816.81-2174.53)] ,其次是 NSTEMI [955.50 (619.99-1576-06)] 和 USAP [595.32 (437.52-918.27)] (P<0.001)。SII 预测中期死亡率的成功率中等(AUC:0.653,95% CI:0.526-0.779,p=0.024)。在多变量分析中,SII每增加100个单位,中期死亡风险就会增加2%(OR:1.020,95% CI:1.004-1.037,P=0.016):我们的研究表明,SII水平较高的ACS患者在12个月内的死亡风险较高,SII水平较高与更严重的潜在ACS病因有关。如果得到前瞻性证据的支持,SII 指数可在 ACS 严重程度和随后的一年生存率方面为临床医生提供指导。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Association Between Systemic Immune Inflammation Index and Intermediate-Term Mortality in Patients with Acute Coronary Syndromes
Background: ic immune inflammation has been investigated as a prognostic marker for different disea-ses. Considering the pivotal role of inflammation in the pathogenesis of acute coronary syndrome (ACS), it is paramount to predict the prognosis of patients with ACS. Therefore, we evaluated the association between inflammation measured by the systemic immune-inflammation index (SII) and middle-term mortality in patients with ACS. Materials and Methods: This single-center, retrospective study was composed of 539 patients with ACS (139 unstable angina pectoris [USAP], 165 non-ST-elevation myocardial infarction [NSTEMI], and 235 ST-elevation myocardial infarction [STEMI]) aged over 18 years. Descriptive statistics and multivari-ate regressions were used to examine the association between clinical and laboratory parameter characteristics and 12-month mortality. Results: The median age of the patients was 58 (50-67) and 73.1% of the patients were male. A total of 20 patients died in the next twelve months after ACS event. The median SII levels were highest in patients with STEMI [1301.96 (816.81-2174.53)] , followed by NSTEMI [955.50 (619.99-1576-06] and USAP [595.32 (437.52-918.27)] (p<0.001). The SII had moderate success for the prediction of the intermediate-term mortality (AUC: 0.653, 95% CI: 0.526-0.779, p=0.024). In multivariate analyses, every 100-unit increase in SII was associated with a two percent increase in the risk of intermediate mortality (OR: 1.020, 95% CI: 1.004-1.037, p=0.016). Conclusions: We demonstrated that ACS patients with higher SII levels had a higher risk of mortality at twelve months, and higher SII levels were associated with a more severe underlying ACS etiology. If supported by prospective evidence, the SII index may guide clinicians in terms of both ACS severity and subsequent one-year survival rates.
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