用于骨再生的 PCL/Estradiol 电纺丝膜的形态和特性分析

Dida Faadihilah Khrisna, N. M. Zain, Nurizzati Mohd Daud, Faizuan Abdullah, Nik Ahmad Nizam Nik Malek, S. Saidin
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引用次数: 0

摘要

由于现有程序的复杂性和相关风险,目前广泛的研究重点是寻找骨再生的替代疗法。其中一种正在研究的替代方法是利用电纺丝方法制造的可生物降解纳米纤维膜。本研究以聚己内酯(PCL)为主要基质,在不同的电纺参数下形成电纺膜,并加入雌二醇以解决骨再生能力问题。在通过形态、化学功能和润湿性分析确定合适的电纺参数的同时,研究了在 PCL 膜中加入雌二醇的影响。在 PCL 基质中加入雌二醇后,纳米纤维的直径减小了,膜的润湿性也得到了改善。电纺电压和流速的改变也影响了纤维直径和润湿性的减小,这凸显了该膜进一步用于细胞附着和骨再生的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Morphological and Characterization Analysis of PCL/Estradiol Electrospun Membrane for Bone Regeneration Application
Extensive research is currently focused on finding alternative treatment for bone regeneration, due to the complexity and risks associated with existing procedures. One such alternative under investigation is the utilization of biodegradable nanofiber membranes, fabricated using an electrospinning method. In this study, polycaprolactone (PCL) was used as the main matrix to form electrospun membranes at different electrospinning parameters with the incorporation of estradiol to address bone regeneration capability. The effects of estradiol incorporation within the PCL membranes while determining the appropriate electrospinning parameters through morphological, chemical functionalities and wettability analyses were investigated. The inclusion of estradiol into the PCL matrix has reduced the nanofiber diameter and improved the wettability properties of the membranes. The alterations of electrospinning voltage and flow rate also impacted on the reduction of fiber diameter and wettability, which highlights the membrane’s potential for further cell attachment and bone regeneration.
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