一例 5 岁儿童因急性肠道感染并发小肠结肠炎而导致的溶血性尿毒症综合征病例

O. V. Molochkova, S. B. Orekhova, R. V. Ovechkin, V. S. Vyshlova, V. V. Glukhova, O. Kovalev, N. Y. Egorova, A. Chashchukhina, V. A. Masyakin, E. P. Egorova, A. A. Sakharova, A. G. Okhtyarkina
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引用次数: 0

摘要

目的:展示一例 5 岁儿童溶血性尿毒症(HUS)病例,该病例与病因不明的急性肠道感染有关,并伴有小儿结肠炎。结果。在临床和实验室观察期间,患儿出现了水肿综合征、少尿症、严重的微血管病性溶血性贫血(血红蛋白、血红蛋白下降,乳酸脱氢酶升高)、血小板减少症、消耗性凝血病、高氮血症、KDIGO 2级急性肾损伤(血清肌酐升高2倍以上)。作为使用平衡晶体液刺激利尿的复合疗法的一部分,他在住院第 2 天就迅速恢复了利尿功能,而无需使用肾脏替代疗法;他还接受了抗生素、抗凝剂、新鲜冰冻血浆和红细胞悬液的输注。高氮血症和血小板减少症在 5 天内得到缓解。后续的肾功能恢复情况显示:
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A case of hemolytic-uremic syndrome that developed in a 5-year-old child due to acute intestinal infection with hemocolitis
Purpose: to demonstrate a case of hemolytic-uremic syndrome (HUS) in a 5-year-old child associated with an acute intestinal infection of unknown etiology, occurring with hemocolitis. Results. During clinical and laboratory observation, edematous syndrome, oligoanuria, severe microangiopathic hemolytic anemia (decrease in hemoglobin, haptoglobin, increase in Lactate dehydrogenase), thrombocytopenia, consumption coagulopathy, hyperazotemia, acute kidney injury (AKI) according to KDIGO grade 2 (increase in serum creatinine more than 2 times) developed. As part of complex therapy with balanced crystalloid solutions with stimulation of diuresis, it was possible to achieve rapid restoration of diuresis on the 2nd day of hospital stay without the use of renal replacement therapy; he also received antibiotics, anticoagulants, transfusion of fresh frozen plasma and red blood cell suspension. Hyperazotemia was relieved within 5 days, as was thrombocytopenia. The follow-up recovery of renal function showed.
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