用于口服抗癌药物递送的交联明胶-沸石 Y 混合物释放泽润邦的动力学和机理

Q3 Chemical Engineering

Journal of Advanced Research in Fluid Mechanics and Thermal Sciences Pub Date : 2024-03-25 DOI:10.37934/arfmts.115.1.181192

Norashikin Salleh, Mohd Muzamir Mahat, Sabrina M. Yahaya, Rosmamuhamadani Ramli

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引用次数: 0

摘要

通过在明胶溶液中均匀加入载药沸石 Y，实现了天然抗癌药物的口服剂型--沸石 Y-明胶混合膜。利用计算和实验方法分析了药物的能力，通过 BET 方法分析了药物的包封效率，并通过傅立叶变换红外光谱分析了可能的相互作用。在模拟人体胃肠道条件的 pH 值为 1.2 和 pH 值为 7.4 的条件下释放了 24 小时的泽润邦，并通过合适的数学模型进行了动力学研究，以确定药物释放的主导因素，结果表明可以实现每日一次口服剂型的持续给药。

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Kinetic and Mechanism of Zerumbone Release from Cross-linked Gelatin-Zeolite Y Hybrid for Oral Anticancer Drug Delivery

A hybrid of zeolite Y-gelatin film as an oral dosage form for the natural anticancer drug was achieved by homogenously incorporating the drug-loaded zeolite Y into the gelatin solution. Drug ability was analyzed using computational and experimental approaches, drug encapsulation efficiency via the BET method, and possible interactions by FTIR analyses. Zerumbone released was done in both pH 1.2 and pH 7.4 mimicking the human gastrointestinal tract conditions for 24 hrs and subjected to kinetics study via suitable mathematical models to determine what governs the drug release with the results indicating that a sustained delivery of once-daily oral dosage form could be achieved.

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来源期刊

Journal of Advanced Research in Fluid Mechanics and Thermal Sciences Chemical Engineering-Fluid Flow and Transfer Processes

CiteScore

2.40

自引率

0.00%

发文量

176

期刊介绍： This journal welcomes high-quality original contributions on experimental, computational, and physical aspects of fluid mechanics and thermal sciences relevant to engineering or the environment, multiphase and microscale flows, microscale electronic and mechanical systems; medical and biological systems; and thermal and flow control in both the internal and external environment.