癌症治疗后的道路:生物材料和组织工程方法调解癌症治疗后的肿瘤微环境

Lorna Westwood, Iain J. Nixon, Elaine Emmerson, Anthony Callanan
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引用次数: 0

摘要

癌症每年影响着全球数千万人口,死亡率极高。众所周知,为了有效治疗实体瘤癌症,目前使用的治疗方法往往会牺牲周围的健康组织,在治疗部位造成损伤,引起周围微环境的变化。这些微环境的变化会导致不良副作用和长期损害,甚至在病情缓解后仍会对患者的生活质量产生不利影响。人们相信,通过调节治疗后的肿瘤微环境(TME),不仅可以提高现有治疗方法的疗效,还有可能减少这些相关的负面副作用以及治疗引起的进一步并发症,包括转移。调节微环境也被认为有助于治疗后修复受损部位,从而为促进再生过程创造更有利的条件。本综述简要概述了化疗、放疗和手术这三种主要的癌症治疗方法对肿瘤微环境造成的改变,以及目前用于调解癌症治疗后肿瘤微环境的最常用组织工程方法。此外,报告还研究了该领域的新兴技术以及这些方法在临床应用方面的进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The road after cancer: biomaterials and tissue engineering approaches to mediate the tumor microenvironment post-cancer treatment
Cancer affects tens of millions of the world’s population each year with a stark mortality rate. It is well established that in order to be effective in treating solid tumor cancers, the current treatment methods used often sacrifice surrounding healthy tissue and cause damage at the site of treatment, inducing changes to the surrounding microenvironment. These changes to the microenvironment can lead to adverse side effects as well as long-term damage which continues to have a detrimental impact on the patient’s quality of life, even after remission. It is believed that by modulating the tumor microenvironment (TME) post-treatment, not only may the efficacy of current treatments be improved, but such associated negative side effects, as well as further complications arising from treatment, including metastasis, have the potential to be reduced. Mediating the microenvironment is also considered to aid in repairing the damaged site post-treatment, subsequently making the conditions more favourable for promoting regenerative processes. This review provides a brief overview of the alterations in the TME resulting from the three main cancer treatments–chemotherapy, radiation therapy and surgery–and the most common tissue engineering methods currently used in an attempt to mediate the TME post-cancer therapy. Furthermore, it investigates new emerging technologies within this field and the progress of such methods in terms of reaching the clinical setting.
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