三级医疗中心性腺和性腺外畸胎瘤的临床组织病理学研究

Fatema Topiwala, Jyoti Gorade, Marium Siddiqui, Dharitri Bhat, Archana Deshpande
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摘要

背景:畸胎瘤通常出现在性腺区域。与性腺畸胎瘤相比,性腺外畸胎瘤非常罕见。它们可以是成熟的、未成熟的、恶性的或混合性的生殖细胞瘤。由于畸胎瘤发生在腹膜后、骶尾部、纵隔、甲状腺、眼部、耳部和肠系膜等罕见部位,临床上经常会漏诊。在这些部位,临床上需要鉴别的病例很多,临床医生很难做出准确的临床诊断。本研究的目的是:确定对角线外畸胎瘤的不同部位,了解不同部位畸胎瘤的组织学类型,并将组织病理学诊断与临床放射学诊断联系起来:这是一项观察性描述性研究,研究对象是2021年7月至2023年7月两年内经组织病理学证实的畸胎瘤:结果:在35例畸胎瘤中,有14例为对角线外畸胎瘤。最常见的部位是骶尾部。这些畸胎瘤最常见于儿科年龄组,最常累及的性别是男性:在解释组织病理学结果时,即使畸胎瘤的部位不是性腺,也需要保持高度的怀疑。简单切除即可治愈,否则可能转化为恶性肿瘤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinico-histopathological study of gonadal and extragonadal teratomas in tertiary care centre
Background: Teratomas are quite often seen in the gonadal region. As compared to gonadal teratoma extragonadal teratomas are very rare. They can be mature, immature, malignant or mixed germ cell tumor. Many a times they are missed clinically because of their rare locations that include retroperitoneum, sacrococcygeal, mediastinum, thyroid, eye, ear, and mesentery. In such locations the list of clinical differentials is long and it is difficult for the clinicians to make an accurate clinical diagnosis. Aims of the study were: to identify the different locations of extragonadal teratoma, to know the histological types of teratoma in different location, and to correlate histopathological diagnosis and clinico-radiological diagnosis. Methods: It is an observational descriptive study of histopathologically proven teratomas over a span of 2 years from July 2021 to July 2023. Results: Out of total 35 cases of teratomas, we had received 14 cases of extragonadal teratomas. The most common sites being sacrococcygeal region. They were most common in the paediatrics age group and most common sex involvement was of male. Conclusions: While interpreting the histopathological findings, a high index of suspicion for teratomas needs to be kept even if the site is not a gonadal location. Simple excision is a cure for this condition or else it may transform to malignancy.
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