槲皮素类化合物生物活性的比较评估

D. O. Tsymbal
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引用次数: 0

摘要

目的根据含氧官能团络合活性的比较分析,确定多种黄酮类化合物中槲皮素类化合物的抗氧化、肿瘤保护和抗炎特性的表现程度。 材料和方法对文献资料进行分析和系统化,采用合理的方法建立分子系统特性模型。 结果。结果表明,确定各种黄酮类化合物分子独立部分的结构特征,对于随后确定其生物特性的相关程度十分有利。 结论比较植物来源物质的生物特性,并结合应用最新的提取方法,将有助于在获得新活性物质的阶段加快药物开发。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparative evaluation of the biological activity of quercetin-like compounds
   Objective. To determine the degree of manifestation of antioxidant, oncoprotective, anti-inflammatory properties of quercetin-like compounds of a number of flavonoids based on a comparative analysis of the complexing activity of oxygen-containing functional groups.   Materials and methods. Analysis and systematization of literary data, a rationalistic method of modeling the properties of molecular systems.   Results. The expediency of determining the structural identity of separate sections of molecules of various flavonoids for the subsequent determination of the degree of correlation of their biological properties is shown.   Conclusion. Comparison of biological properties of substances of plant origin in combination with application of the latest extraction methods will help to accelerate drug development at the stage of obtaining a new active substance.
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