槲皮素和 Omega-3 脂肪酸对蚊香烟雾诱导的雄性 Wistar 大鼠血液学和肝功能损伤的改善作用

Q4 Immunology and Microbiology

Nigerian Journal of Parasitology Pub Date : 2024-03-28 DOI:10.4314/njpar.v45i1.14

E. Aribo, S. U. Uquetan, S. U. Phillip, A. O. Uduak

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引用次数: 0

摘要

吸入蚊香烟雾会造成不良影响，包括与氧化应激有关的肝脏和血液毒性。因此，本研究调查了植物化学抗氧化剂（槲皮素和欧米茄-3）对蚊香烟雾引起的血液学和肝脏损伤的影响。20 只雄性 Wistar 大鼠被分为 4 组，即对照组、蚊香组（MC）、蚊香+槲皮素组（MC+Q）和蚊香+Omega-3 组（MC+OM3），每组 5 只。槲皮素和 Omega-3 的剂量分别为 20 毫克/千克和 600 毫克/千克。每天接触和治疗的持续时间为 42 天，之后通过心脏穿刺采集血液样本，测定相关的血液学和肝脏参数。与对照组相比，MC 组的红细胞计数明显减少（P<0.05），但 MC+ 槲皮素组的红细胞计数高于 MC 组。与对照组相比，MC 组和 MC+Omega-3 组的血红蛋白降低（P<0.05）。MC 组的白细胞计数高于对照组（P<0.05），但 MC+OM3 组和 MC+Q 组的白细胞计数低于 MC 组（P<0.05）。MC组的淋巴细胞计数高于对照组（P<0.05）。与对照组相比，MC 组血清天冬氨酸转氨酶和丙氨酸转氨酶明显升高（P<0.05），但与 MC 组相比，MC+OM3 组和 MC+Q 组血清天冬氨酸转氨酶和丙氨酸转氨酶降低（P<0.05）。MC 组血清碱性磷酸酶明显高于对照组（P<0.05），但 MC+OM3 组明显低于 MC 组（P<0.05）。与对照组相比，MC 组血清总胆红素明显升高（P<0.05）。MC组的血清直接胆红素浓度明显高于对照组（P<0.05）。我们的结论是，Omega-3 和槲皮素可改善暴露于蚊香烟雾的 Wistar 大鼠的血液学和肝功能损伤。

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Ameliorative effect of Quercetin and Omega-3 Fatty Acids on haematological and liver function impairment induced by mosquito coil smoke in male Wistar rats

The use of mosquito coils is one method adopted to control malaria Inhalation of the coil smoke causes adverse effects, including hepatic and haematological toxicities associated with oxidative stress. Therefore, this study investigated the effects of phytochemical antioxidants (Quercetin and Omega-3) on mosquito coil smoke-induced haematological and hepatic impairments. Twenty male Wistar rats were divided into 4 groups viz control, mosquito coil-only (MC), mosquito coil+Quercetin (MC+Q) and mosquito coil+Omega-3 (MC+OM3) groups of five rats each. Quercetin and Omega-3 were administered daily at 20mg/kg and 600mg/kg respectively. The duration of daily exposure and treatment was 42 days after which blood samples were collected via cardiac puncture for determination of relevant haematological and hepatic parameters. The RBC count was significantly reduced in the MC group compared with the control (P<0.05) but was higher in the MC+Quercetin group than in the MC group. Haemoglobin was decreased in the MC and MC+Omega-3 groups compared with the control (P<0.05). White blood cell count was higher in the MC group than in the control group (P<0.05) but lower in the MC+OM3 and MC+Q groups than in the MC group (P<0.05). The lymphocyte count was higher in the MC group than in the control group (P<0.05). Serum aspartate transaminase and alanine transaminase were significantly increased (P<0.05) in the MC group compared with the control group but were reduced (P<0.05) in the MC+OM3 and MC+Q groups compared with the MC group. Serum alkaline phosphatase was significantly higher (P<0.05) in the MC group than in control (P<0.05) but significantly lower (P<0.05) in the MC+OM3 group than in the MC group. Serum total bilirubin was significantly elevated in the MC group compared to that in the control group (P<0.05). The serum concentration of direct bilirubin was significantly higher (P<0.05) in the MC group than in the control group. We conclude that Omega-3 and Quercetin ameliorate haematological and hepatic function impairments in Wistar rats exposed to mosquito coil smoke.

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来源期刊

Nigerian Journal of Parasitology Medicine-Infectious Diseases

CiteScore

0.20

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0.00%

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