评估计算机断层扫描在高危子宫内膜癌监测中的实用性

Q3 Medicine
Taliya Lantsman , Corinne Jansen , Elysia Larson , Katharine Esselen , Meghan Shea
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引用次数: 0

摘要

目的子宫内膜癌是一种具有不同组织学和分子亚型的癌症,其风险特征各不相同。不同医疗机构对高风险子宫内膜癌的监测方案各不相同。美国国立综合癌症网络(NCCN)建议,无论癌症分期和组织学如何,所有子宫内膜癌在缓解后都应进行基于症状和检查的监测。我们的目标是确定检测高危子宫内膜癌复发的第一种方法,并研究疾病复发和治疗模式。方法 一家大型学术机构对 2013 年 11 月至 2020 年 2 月期间诊断为高危子宫内膜癌的患者进行了回顾性研究。高危子宫内膜癌按组织学和病理学分期进行分类,并按主要检测方法进行分类。结果发现 229 例高危子宫内膜癌患者,其中 63 例(28%)复发。大多数复发是通过常规影像学检查首次发现的,占 31 例(49.2%),症状监测占 24 例(38.15%)。无论采用哪种检测方法,大多数患者都接受了系统治疗。结论在我们的高危子宫内膜癌队列中,最常见的复发部位是肺部,大多数复发是通过无症状造影发现的。虽然接受造影监测者的生存率与接受标准治疗者的生存率在统计学上没有显著差异,但两者的生存率呈上升趋势,需要在更大的队列中进一步探讨。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An evaluation of the utility of computed tomography in high-risk endometrial cancer surveillance

Objectives

Endometrial cancer is a collection of heterogeneous histologies and molecular subtypes with different risk profiles. High-risk endometrial cancer surveillance regimens vary amongst providers. The National Comprehensive Cancer Network (NCCN) recommends symptom and exam-based surveillance for all endometrial cancers after remission, regardless of cancer stage and histology. Our objective was to identify the first method of detection of recurrence in high-risk endometrial cancers and examine disease recurrence and treatment patterns.

Methods

A retrospective review of patients diagnosed with high-risk endometrial cancer between November 2013 and February 2020 was conducted at a large academic institution. High-risk endometrial cancers were classified by histology and pathologic stage and were categorized by primary method of detection.

Results

Two hundred and twenty-nine patients were identified with high-risk endometrial cancer, 63 (28 %) of whom had a recurrence. Most recurrences were first detected with routine imaging in 31 patients (49.2 %) and symptom surveillance in 24 patients (38.15 %). Regardless of the detection method, most patients underwent systemic treatment. The average survival after recurrence was 2.0 years in the imaging cohort and 1.6 years in the non-imaging surveillance cohort.

Conclusions

The most common site of recurrence in our cohort of high-risk endometrial cancer was in the lung, and most recurrences were identified with asymptomatic imaging. Though there was no statistically significant difference between the survival of those who underwent imaging surveillance vs. standard of care, there was a trend toward survival that deems further exploration with a larger cohort.

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来源期刊
CiteScore
4.30
自引率
0.00%
发文量
148
审稿时长
56 days
期刊介绍: Cancer Treatment and Research Communications is an international peer-reviewed publication dedicated to providing comprehensive basic, translational, and clinical oncology research. The journal is devoted to articles on detection, diagnosis, prevention, policy, and treatment of cancer and provides a global forum for the nurturing and development of future generations of oncology scientists. Cancer Treatment and Research Communications publishes comprehensive reviews and original studies describing various aspects of basic through clinical research of all tumor types. The journal also accepts clinical studies in oncology, with an emphasis on prospective early phase clinical trials. Specific areas of interest include basic, translational, and clinical research and mechanistic approaches; cancer biology; molecular carcinogenesis; genetics and genomics; stem cell and developmental biology; immunology; molecular and cellular oncology; systems biology; drug sensitivity and resistance; gene and antisense therapy; pathology, markers, and prognostic indicators; chemoprevention strategies; multimodality therapy; cancer policy; and integration of various approaches. Our mission is to be the premier source of relevant information through promoting excellence in research and facilitating the timely translation of that science to health care and clinical practice.
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