槲皮素通过 MAPK/PTGS2 通路抑制铁凋亡，从而缓解高氧诱导的支气管肺发育不良：网络药理学、分子对接和实验评估的启示

IF 3.2 4区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Chemical Biology & Drug Design Pub Date : 2024-04-03 DOI:10.1111/cbdd.14520

Xianhui Deng, Dan Chen, Anni Xie, Shengpeng Li, Ailing Chen, Qin Zhou, Renqiang Yu

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引用次数: 0

摘要

槲皮素是一种具有生物活性的天然化合物，因其强大的抗炎、抗氧化和抗病毒特性而闻名，在多种疾病中具有治疗潜力。鉴于支气管肺发育不良（BPD）的发展与炎症和氧化应激密切相关，而槲皮素是一种强效抗氧化剂，可激活 NRF2 并影响铁氧化途径，因此有望用于各种年龄段的人群。然而，槲皮素在 BPD 中的具体作用在很大程度上仍未得到探索。本研究旨在通过结合网络药理学、分子对接、计算机分析和实验评估，揭示槲皮素在 BPD 中的靶向作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Quercetin alleviates hyperoxia-induced bronchopulmonary dysplasia by inhibiting ferroptosis through the MAPK/PTGS2 pathway: Insights from network pharmacology, molecular docking, and experimental evaluations

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Quercetin, a bioactive natural compound renowned for its potent anti-inflammatory, antioxidant, and antiviral properties, has exhibited therapeutic potential in various diseases. Given that bronchopulmonary dysplasia (BPD) development is closely linked to inflammation and oxidative stress, and quercetin, a robust antioxidant known to activate NRF2 and influence the ferroptosis pathway, offers promise for a wide range of age groups. Nonetheless, the specific role of quercetin in BPD remains largely unexplored. This study aims to uncover the target role of quercetin in BPD through a combination of network pharmacology, molecular docking, computer analyses, and experimental evaluations.

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来源期刊

Chemical Biology & Drug Design 医学-生化与分子生物学

CiteScore

5.10

自引率

3.30%

发文量

164

审稿时长

4.4 months

期刊介绍： Chemical Biology & Drug Design is a peer-reviewed scientific journal that is dedicated to the advancement of innovative science, technology and medicine with a focus on the multidisciplinary fields of chemical biology and drug design. It is the aim of Chemical Biology & Drug Design to capture significant research and drug discovery that highlights new concepts, insight and new findings within the scope of chemical biology and drug design.