Hyun Sue Kim, Soshian Sarrafpour, Christopher C Teng, Ji Liu
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引用次数: 0
摘要
人类眼部胚胎学的复杂步骤受到细胞和遗传信号通路以及环境、新陈代谢、激素因素、药物和宫内感染等众多外部因素的影响。本综述重点介绍其中的一些因素,以认识眼部发育的多因素性质,并强调其临床意义。本综述基于来自 PubMed、Web of Science 和 Google Scholar 的英文文章;搜索关键词包括 "妊娠期眼部发育"、"眼胚胎学"、"母体营养"、"眼部变化 "和 "视觉系统发育"。虽然一些动物模型显示了这些外部因素对眼部胚胎的破坏,但人类研究对出生后的评估却很有限。关于这些外部因素如何在子宫内破坏正常眼部发育的确切机制,仍有许多未知之处,需要进行更多的研究,以进一步了解这些破坏性影响的病理生理学。本综述中的发现强调了开展更多研究以了解影响妊娠和新生儿眼部发育的因素之间的动态关联的重要性,尤其是在资源有限的情况下。
External Disruption of Ocular Development in Utero.
The intricate steps of human ocular embryology are impacted by cellular and genetic signaling pathways and a myriad of external elements that can affect pregnancy, such as environmental, metabolic, hormonal factors, medications, and intrauterine infections. This review focuses on presenting some of these factors to recognize the multifactorial nature of ocular development and highlight their clinical significance. This review is based on English-language articles sourced from PubMed, Web of Science, and Google Scholar; keywords searched included "ocular development in pregnancy," "ocular embryology," "maternal nutrition," "ophthalmic change," and "visual system development." While some animal models show the disruption of ocular embryology from these external factors, there are limited post-birth assessments in human studies. Much remains unknown about the precise mechanisms of how these external factors can disrupt normal ocular development in utero, and more significant research is needed to understand the pathophysiology of these disruptive effects further. Findings in this review emphasize the importance of additional research in understanding the dynamic association between factors impacting gestation and neonatal ocular development, particularly in the setting of limited resources.
期刊介绍:
The Yale Journal of Biology and Medicine (YJBM) is a graduate and medical student-run, peer-reviewed, open-access journal dedicated to the publication of original research articles, scientific reviews, articles on medical history, personal perspectives on medicine, policy analyses, case reports, and symposia related to biomedical matters. YJBM is published quarterly and aims to publish articles of interest to both physicians and scientists. YJBM is and has been an internationally distributed journal with a long history of landmark articles. Our contributors feature a notable list of philosophers, statesmen, scientists, and physicians, including Ernst Cassirer, Harvey Cushing, Rene Dubos, Edward Kennedy, Donald Seldin, and Jack Strominger. Our Editorial Board consists of students and faculty members from Yale School of Medicine and Yale University Graduate School of Arts & Sciences. All manuscripts submitted to YJBM are first evaluated on the basis of scientific quality, originality, appropriateness, contribution to the field, and style. Suitable manuscripts are then subject to rigorous, fair, and rapid peer review.