{"title":"水相次氯酸水和雾化次氯酸水对 SARS-CoV-2 的杀毒功效","authors":"Makoto Kubo, Ryotaro Eda, Shotaro Maehana, Hiroshi Fuketa, Norihiro Shinkai, Naohisa Kawamura, Hidero Kitasato, Hideaki Hanaki","doi":"10.2166/wh.2024.348","DOIUrl":null,"url":null,"abstract":"<div><div data- reveal-group-><div><img alt=\"graphic\" data-src=\"https://iwa.silverchair-cdn.com/iwa/content_public/journal/jwh/22/3/10.2166_wh.2024.348/1/m_jwh-d-23-00348gf01.png?Expires=1714744915&Signature=2b92V63jse9OiyGI6yc219mHK2v7JmgIbl4an3h8GnflcUtEn7LWZjPOrb9x-nUNVG530GL4vFL8hAB0fbqjTaSU~Fzmck4DLM9mkH19bsodFuMIfGw-Tv0BNHKoD3uWb~YJBij~IB1DyawHMPbp1vQ4Z00jdTRAJu8wcPQX1nKQ5rQ2HhM6Eeh30-jOvCOlmpBzfPn~MGVzFDOvqHTiR2zNRfXxYNpfqCl94DfI6kHvraxXx-ntFtr9TTEoJLgZ7sk6k0TEZDNitzNWuNla3hbu9Y7KtvOvAxDE1MrCmrZcQVHoJfDyhdj9O8DXC~Rk2iHXt~lhMD-gOHKgflAOhA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA\" path-from-xml=\"jwh-d-23-00348gf01.tif\" src=\"https://iwa.silverchair-cdn.com/iwa/content_public/journal/jwh/22/3/10.2166_wh.2024.348/1/m_jwh-d-23-00348gf01.png?Expires=1714744915&Signature=2b92V63jse9OiyGI6yc219mHK2v7JmgIbl4an3h8GnflcUtEn7LWZjPOrb9x-nUNVG530GL4vFL8hAB0fbqjTaSU~Fzmck4DLM9mkH19bsodFuMIfGw-Tv0BNHKoD3uWb~YJBij~IB1DyawHMPbp1vQ4Z00jdTRAJu8wcPQX1nKQ5rQ2HhM6Eeh30-jOvCOlmpBzfPn~MGVzFDOvqHTiR2zNRfXxYNpfqCl94DfI6kHvraxXx-ntFtr9TTEoJLgZ7sk6k0TEZDNitzNWuNla3hbu9Y7KtvOvAxDE1MrCmrZcQVHoJfDyhdj9O8DXC~Rk2iHXt~lhMD-gOHKgflAOhA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA\"/><div>View largeDownload slide</div></div></div><div content- data-reveal=\"data-reveal\"><div><img alt=\"graphic\" data-src=\"https://iwa.silverchair-cdn.com/iwa/content_public/journal/jwh/22/3/10.2166_wh.2024.348/1/m_jwh-d-23-00348gf01.png?Expires=1714744915&Signature=2b92V63jse9OiyGI6yc219mHK2v7JmgIbl4an3h8GnflcUtEn7LWZjPOrb9x-nUNVG530GL4vFL8hAB0fbqjTaSU~Fzmck4DLM9mkH19bsodFuMIfGw-Tv0BNHKoD3uWb~YJBij~IB1DyawHMPbp1vQ4Z00jdTRAJu8wcPQX1nKQ5rQ2HhM6Eeh30-jOvCOlmpBzfPn~MGVzFDOvqHTiR2zNRfXxYNpfqCl94DfI6kHvraxXx-ntFtr9TTEoJLgZ7sk6k0TEZDNitzNWuNla3hbu9Y7KtvOvAxDE1MrCmrZcQVHoJfDyhdj9O8DXC~Rk2iHXt~lhMD-gOHKgflAOhA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA\" path-from-xml=\"jwh-d-23-00348gf01.tif\" src=\"https://iwa.silverchair-cdn.com/iwa/content_public/journal/jwh/22/3/10.2166_wh.2024.348/1/m_jwh-d-23-00348gf01.png?Expires=1714744915&Signature=2b92V63jse9OiyGI6yc219mHK2v7JmgIbl4an3h8GnflcUtEn7LWZjPOrb9x-nUNVG530GL4vFL8hAB0fbqjTaSU~Fzmck4DLM9mkH19bsodFuMIfGw-Tv0BNHKoD3uWb~YJBij~IB1DyawHMPbp1vQ4Z00jdTRAJu8wcPQX1nKQ5rQ2HhM6Eeh30-jOvCOlmpBzfPn~MGVzFDOvqHTiR2zNRfXxYNpfqCl94DfI6kHvraxXx-ntFtr9TTEoJLgZ7sk6k0TEZDNitzNWuNla3hbu9Y7KtvOvAxDE1MrCmrZcQVHoJfDyhdj9O8DXC~Rk2iHXt~lhMD-gOHKgflAOhA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA\"/><div>View largeDownload slide</div></div><i> </i><span>Close modal</span></div></div><p>Coronavirus disease 2019 (COVID-19) is an infectious viral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that emerged at the end of 2019. SARS-CoV-2 can be transmitted through droplets, aerosols, and fomites. Disinfectants such as alcohol, quaternary ammonium salts, and chlorine-releasing agents, including hypochlorous acid, are used to prevent the spread of SARS-CoV-2 infection. In the present study, we investigated the efficacy of ionless hypochlorous acid water (HOCl) in suspension and by spraying to inactivate SARS-CoV-2. The virucidal efficacy of HOCl solution in tests against SARS-CoV-2 was evaluated as 50% tissue culture infectious dose. Although the presence of organic compounds influenced the virucidal efficacy, HOCl treatment for 20 s was significantly effective to inactivate Wuhan and Delta strains in the suspension test. HOCl atomization for several hours significantly reduced the SARS-CoV-2 attached to plastic plates. These results indicate that HOCl solution with elimination containing NaCl and other ions may have high virucidal efficacy against SARS-CoV-2. This study provides important information about the virucidal efficacy and use of HOCl solution.</p>","PeriodicalId":518003,"journal":{"name":"Journal of Water & Health","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Virucidal efficacy of hypochlorous acid water for aqueous phase and atomization against SARS-CoV-2\",\"authors\":\"Makoto Kubo, Ryotaro Eda, Shotaro Maehana, Hiroshi Fuketa, Norihiro Shinkai, Naohisa Kawamura, Hidero Kitasato, Hideaki Hanaki\",\"doi\":\"10.2166/wh.2024.348\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div data- reveal-group-><div><img alt=\\\"graphic\\\" data-src=\\\"https://iwa.silverchair-cdn.com/iwa/content_public/journal/jwh/22/3/10.2166_wh.2024.348/1/m_jwh-d-23-00348gf01.png?Expires=1714744915&Signature=2b92V63jse9OiyGI6yc219mHK2v7JmgIbl4an3h8GnflcUtEn7LWZjPOrb9x-nUNVG530GL4vFL8hAB0fbqjTaSU~Fzmck4DLM9mkH19bsodFuMIfGw-Tv0BNHKoD3uWb~YJBij~IB1DyawHMPbp1vQ4Z00jdTRAJu8wcPQX1nKQ5rQ2HhM6Eeh30-jOvCOlmpBzfPn~MGVzFDOvqHTiR2zNRfXxYNpfqCl94DfI6kHvraxXx-ntFtr9TTEoJLgZ7sk6k0TEZDNitzNWuNla3hbu9Y7KtvOvAxDE1MrCmrZcQVHoJfDyhdj9O8DXC~Rk2iHXt~lhMD-gOHKgflAOhA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA\\\" path-from-xml=\\\"jwh-d-23-00348gf01.tif\\\" src=\\\"https://iwa.silverchair-cdn.com/iwa/content_public/journal/jwh/22/3/10.2166_wh.2024.348/1/m_jwh-d-23-00348gf01.png?Expires=1714744915&Signature=2b92V63jse9OiyGI6yc219mHK2v7JmgIbl4an3h8GnflcUtEn7LWZjPOrb9x-nUNVG530GL4vFL8hAB0fbqjTaSU~Fzmck4DLM9mkH19bsodFuMIfGw-Tv0BNHKoD3uWb~YJBij~IB1DyawHMPbp1vQ4Z00jdTRAJu8wcPQX1nKQ5rQ2HhM6Eeh30-jOvCOlmpBzfPn~MGVzFDOvqHTiR2zNRfXxYNpfqCl94DfI6kHvraxXx-ntFtr9TTEoJLgZ7sk6k0TEZDNitzNWuNla3hbu9Y7KtvOvAxDE1MrCmrZcQVHoJfDyhdj9O8DXC~Rk2iHXt~lhMD-gOHKgflAOhA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA\\\"/><div>View largeDownload slide</div></div></div><div content- data-reveal=\\\"data-reveal\\\"><div><img alt=\\\"graphic\\\" data-src=\\\"https://iwa.silverchair-cdn.com/iwa/content_public/journal/jwh/22/3/10.2166_wh.2024.348/1/m_jwh-d-23-00348gf01.png?Expires=1714744915&Signature=2b92V63jse9OiyGI6yc219mHK2v7JmgIbl4an3h8GnflcUtEn7LWZjPOrb9x-nUNVG530GL4vFL8hAB0fbqjTaSU~Fzmck4DLM9mkH19bsodFuMIfGw-Tv0BNHKoD3uWb~YJBij~IB1DyawHMPbp1vQ4Z00jdTRAJu8wcPQX1nKQ5rQ2HhM6Eeh30-jOvCOlmpBzfPn~MGVzFDOvqHTiR2zNRfXxYNpfqCl94DfI6kHvraxXx-ntFtr9TTEoJLgZ7sk6k0TEZDNitzNWuNla3hbu9Y7KtvOvAxDE1MrCmrZcQVHoJfDyhdj9O8DXC~Rk2iHXt~lhMD-gOHKgflAOhA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA\\\" path-from-xml=\\\"jwh-d-23-00348gf01.tif\\\" src=\\\"https://iwa.silverchair-cdn.com/iwa/content_public/journal/jwh/22/3/10.2166_wh.2024.348/1/m_jwh-d-23-00348gf01.png?Expires=1714744915&Signature=2b92V63jse9OiyGI6yc219mHK2v7JmgIbl4an3h8GnflcUtEn7LWZjPOrb9x-nUNVG530GL4vFL8hAB0fbqjTaSU~Fzmck4DLM9mkH19bsodFuMIfGw-Tv0BNHKoD3uWb~YJBij~IB1DyawHMPbp1vQ4Z00jdTRAJu8wcPQX1nKQ5rQ2HhM6Eeh30-jOvCOlmpBzfPn~MGVzFDOvqHTiR2zNRfXxYNpfqCl94DfI6kHvraxXx-ntFtr9TTEoJLgZ7sk6k0TEZDNitzNWuNla3hbu9Y7KtvOvAxDE1MrCmrZcQVHoJfDyhdj9O8DXC~Rk2iHXt~lhMD-gOHKgflAOhA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA\\\"/><div>View largeDownload slide</div></div><i> </i><span>Close modal</span></div></div><p>Coronavirus disease 2019 (COVID-19) is an infectious viral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that emerged at the end of 2019. SARS-CoV-2 can be transmitted through droplets, aerosols, and fomites. Disinfectants such as alcohol, quaternary ammonium salts, and chlorine-releasing agents, including hypochlorous acid, are used to prevent the spread of SARS-CoV-2 infection. In the present study, we investigated the efficacy of ionless hypochlorous acid water (HOCl) in suspension and by spraying to inactivate SARS-CoV-2. The virucidal efficacy of HOCl solution in tests against SARS-CoV-2 was evaluated as 50% tissue culture infectious dose. Although the presence of organic compounds influenced the virucidal efficacy, HOCl treatment for 20 s was significantly effective to inactivate Wuhan and Delta strains in the suspension test. HOCl atomization for several hours significantly reduced the SARS-CoV-2 attached to plastic plates. These results indicate that HOCl solution with elimination containing NaCl and other ions may have high virucidal efficacy against SARS-CoV-2. This study provides important information about the virucidal efficacy and use of HOCl solution.</p>\",\"PeriodicalId\":518003,\"journal\":{\"name\":\"Journal of Water & Health\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Water & Health\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2166/wh.2024.348\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Water & Health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2166/wh.2024.348","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Virucidal efficacy of hypochlorous acid water for aqueous phase and atomization against SARS-CoV-2
View largeDownload slide
View largeDownload slide
Close modal
Coronavirus disease 2019 (COVID-19) is an infectious viral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that emerged at the end of 2019. SARS-CoV-2 can be transmitted through droplets, aerosols, and fomites. Disinfectants such as alcohol, quaternary ammonium salts, and chlorine-releasing agents, including hypochlorous acid, are used to prevent the spread of SARS-CoV-2 infection. In the present study, we investigated the efficacy of ionless hypochlorous acid water (HOCl) in suspension and by spraying to inactivate SARS-CoV-2. The virucidal efficacy of HOCl solution in tests against SARS-CoV-2 was evaluated as 50% tissue culture infectious dose. Although the presence of organic compounds influenced the virucidal efficacy, HOCl treatment for 20 s was significantly effective to inactivate Wuhan and Delta strains in the suspension test. HOCl atomization for several hours significantly reduced the SARS-CoV-2 attached to plastic plates. These results indicate that HOCl solution with elimination containing NaCl and other ions may have high virucidal efficacy against SARS-CoV-2. This study provides important information about the virucidal efficacy and use of HOCl solution.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
