盖伦静脉动脉瘤畸形的血管内治疗:两个三级医疗中心的医院病例系列

Wael M. Ali Abdelghany, Radwan Nouby, Osama M. Ramadan, MA. Habib
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引用次数: 0

摘要

盖伦静脉动脉瘤样畸形(VGAM)被认为是一种罕见的血管畸形,占所有动静脉分流的 1%以上。这种畸形约占儿童先天性血管畸形的 30%。我们的研究重点是对患有 Galenic 动静脉分流的儿科患者进行血管内栓塞治疗后的临床和放射学结果进行检查。我们的目的是评估血管内治疗的安全性和有效性。这项研究旨在帮助了解儿科患者 VGAM 的管理和疗效,尤其是在血管内栓塞的情况下。本研究纳入了19例经临床和放射学评估的盖伦静脉畸形患者,我们对他们进行了血管内栓塞治疗,旨在评估2019年5月至2022年12月期间血管内治疗VGA的安全性和有效性。我们对 12 名男性患者(63.2%)和 7 名女性患者(36.8%)进行了评估,他们都是儿科年龄组的盖伦静脉畸形患者。对患者进行了为期一年的随访。我们的研究包括 3 名新生儿(15.8%)、10 名婴儿(52.6%)和 6 名儿童(2-10 岁)(31.6%)。颅骨周长(SC)增加是最常见的症状,共有 8 例(42.1%)。有 15 名患者(78.9%)达到了完全闭塞,4 名患者有残余(21.1%)。11 名患者病情好转(57.9%),2 名患者死亡(10.5%)。VGAM 并非十分罕见,对于患有难治性心力衰竭的儿童患者来说,应牢记这一点。采用血管内栓塞作为主要治疗方法可显著改善预后。根据评分对病例进行良好的选择,并把握好治疗时机,可减少发病率,从而改善预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Endovascular treatment of vein of Galen aneurysmal malformation: hospital-based case series in two tertiary centers
Vein of Galen aneurysmal malformation (VGAM) is considered a rare vascular malformation, constituting over 1% of all arteriovenous shunts. This malformation represents around 30% of congenital vascular malformations in the pediatric population. The focus of our study is to examine both the clinical and radiological outcomes following endovascular embolization in pediatric patients with Galenic arteriovenous shunts. Our aim is to evaluate the safety and efficacy of endovascular management. This research aims to contribute to understanding the management and outcomes of VGAM in pediatric patients, particularly in the context of endovascular embolization. This study included 19 patients with vein of Galen malformation evaluated clinically and radiologically and we treated them with endovascular embolization with aim to assess safety and efficacy of endovascular treatment of VGA in the period from May 2019 to December 2022. We evaluated 12 male patients 63.2% and 7 females 36.8% in pediatric age group with vein of Galen malformation. Patients were followed for 1 year. Our study included 3 neonates (15.8%), 10 infants (52.6%) and 6 children (2–10 years) (31.6%). Increase SC (skull circumference) was the most common presenting symptoms 8 (42.1%). We have reached total occlusion in 15 patients (78.9%) while 4 patients had residual (21.1%). 11 patients improved (57.9%) and 2 patients died (10.5%). VGAM are not very rare and should be kept in mind in children with refractory heart failure. Introduction of endovascular embolization as the primary therapy has significantly improved prognosis. Good selection of cases based on their score and good timing of treatment has impact on prognosis with less morbidities.
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