{"title":"生命起源的稳定蒸馏假说","authors":"Cheng Bi","doi":"arxiv-2403.17072","DOIUrl":null,"url":null,"abstract":"The essence of life is a frequency distribution conversion process of\nmolecules accompanied by changes in information. In wet-dry cycling hot\nsprings, RNA of different sequences continuously undergoes polymerization and\ndecomposition reactions, products with stable configurations will accumulate\ntheir frequency among all RNA molecules and finally become an important source\nof DNA coding and non-coding regions in primitive cells. This periodic extreme\nenvironmental change narrows the frequency distribution of macromolecules\nthrough the distillation process and new potential catalysts are searched. When\nenough macromolecules are accumulated and reliable reaction pathways are built,\nphospholipids randomly wrap the macromolecules in the hot springs which I would\ncall it the pioneer pools, and these protocells become parallel calculators of\nmolecule frequency distribution. Through the selective permeability of the cell\nmembrane to different molecular weights and properties, cells with appropriate\ndistribution have more opportunities to absorb small molecule substances and\nincrease its intracellular frequencies of molecules. This will strongly induce\nthe occurrence of macromolecules that can widely catalyze the synthesis of\nother macromolecules or themselves, such as ribosomes, etc. Rupture and fusion\nduring cell division make all protocells share the same frequency distribution\nof molecules during the origin of life, thus ensuring that all present cells\nhave very similar genetic materials and protein translation systems. This also\nsuggests that viruses may have originated and evolved together with cells.","PeriodicalId":501325,"journal":{"name":"arXiv - QuanBio - Molecular Networks","volume":"12 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Stability distillation hypothesis for the origin of life\",\"authors\":\"Cheng Bi\",\"doi\":\"arxiv-2403.17072\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The essence of life is a frequency distribution conversion process of\\nmolecules accompanied by changes in information. In wet-dry cycling hot\\nsprings, RNA of different sequences continuously undergoes polymerization and\\ndecomposition reactions, products with stable configurations will accumulate\\ntheir frequency among all RNA molecules and finally become an important source\\nof DNA coding and non-coding regions in primitive cells. This periodic extreme\\nenvironmental change narrows the frequency distribution of macromolecules\\nthrough the distillation process and new potential catalysts are searched. When\\nenough macromolecules are accumulated and reliable reaction pathways are built,\\nphospholipids randomly wrap the macromolecules in the hot springs which I would\\ncall it the pioneer pools, and these protocells become parallel calculators of\\nmolecule frequency distribution. Through the selective permeability of the cell\\nmembrane to different molecular weights and properties, cells with appropriate\\ndistribution have more opportunities to absorb small molecule substances and\\nincrease its intracellular frequencies of molecules. This will strongly induce\\nthe occurrence of macromolecules that can widely catalyze the synthesis of\\nother macromolecules or themselves, such as ribosomes, etc. Rupture and fusion\\nduring cell division make all protocells share the same frequency distribution\\nof molecules during the origin of life, thus ensuring that all present cells\\nhave very similar genetic materials and protein translation systems. This also\\nsuggests that viruses may have originated and evolved together with cells.\",\"PeriodicalId\":501325,\"journal\":{\"name\":\"arXiv - QuanBio - Molecular Networks\",\"volume\":\"12 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-03-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"arXiv - QuanBio - Molecular Networks\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/arxiv-2403.17072\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"arXiv - QuanBio - Molecular Networks","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/arxiv-2403.17072","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Stability distillation hypothesis for the origin of life
The essence of life is a frequency distribution conversion process of
molecules accompanied by changes in information. In wet-dry cycling hot
springs, RNA of different sequences continuously undergoes polymerization and
decomposition reactions, products with stable configurations will accumulate
their frequency among all RNA molecules and finally become an important source
of DNA coding and non-coding regions in primitive cells. This periodic extreme
environmental change narrows the frequency distribution of macromolecules
through the distillation process and new potential catalysts are searched. When
enough macromolecules are accumulated and reliable reaction pathways are built,
phospholipids randomly wrap the macromolecules in the hot springs which I would
call it the pioneer pools, and these protocells become parallel calculators of
molecule frequency distribution. Through the selective permeability of the cell
membrane to different molecular weights and properties, cells with appropriate
distribution have more opportunities to absorb small molecule substances and
increase its intracellular frequencies of molecules. This will strongly induce
the occurrence of macromolecules that can widely catalyze the synthesis of
other macromolecules or themselves, such as ribosomes, etc. Rupture and fusion
during cell division make all protocells share the same frequency distribution
of molecules during the origin of life, thus ensuring that all present cells
have very similar genetic materials and protein translation systems. This also
suggests that viruses may have originated and evolved together with cells.