乳酸菌 GG 对减肥手术后患者体重减轻的影响:随机双盲临床试验

Myra Nasir, Samuel Stone, Ian Mahoney, Justin Chang, Julie Kim, Sajani Shah, Laura McDermott, Paola Sebastiani, Hocine Tighiouart, David Snydman, Shira Doron
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引用次数: 0

摘要

引言和目标:越来越多的证据表明,人体肠道微生物群对消化和新陈代谢有影响。据推测,在从食物中吸收能量方面,肥胖者的微生物群比瘦者更有效,因此容易导致体重增加。在接受减肥手术的患者中,肠道微生物群的变化已被证实与手术后体重减轻呈正相关。然而,目前还没有研究调查益生菌对减肥手术后患者体重减轻的影响。我们的研究目的是调查益生菌 Lactobacillus GG(LGG)对减肥手术患者体重减轻和生活质量的影响:该研究已在临床试验网(ClinicalTrials.gov)注册,编号为 NCT01870544。受试者随机接受 LGG 或安慰剂胶囊。计算受试者术后就诊时的总减重百分比,并使用不等式 t 检验法检验两组之间的差异。使用混合模型重复测量模型估算了 LGG 对胃肠道生活质量指数 (GIQLI) 评分的影响:安慰剂组和治疗组在术后 "30 天 "访视时的总重量百分比平均变化率分别为 0.098 和 0.079(p = 0.41),而术后 "90 天 "访视时的总重量百分比平均变化率分别为 0.148 和 0.126(p = 0.18)。术后 "30 天 "和 "90 天 "检查的 GIQLI 评分差异分别为 0.5(-7.1,8.0),p=0.91 和 3.7(-4.9,12.3),p=0.42。在治疗组的 5 名受试者中,有 3 人的粪便中检出了 LGG:接受 LGG 治疗组与接受安慰剂治疗组的平均体重减轻率或 GIQLI 评分没有明显差异。这项研究证明了乳酸菌在胃肠道转运过程中的存活率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of Lactobacillus GG on weight loss in post-bariatric surgery patients: a randomized, double-blind clinical trial
Introduction and Objectives: There is increasing evidence suggesting the impact of human gut microbiota on digestion and metabolism. It is hypothesized that the microbiome in obese subjects is more efficient than that in lean subjects in absorbing energy from food, thus predisposing to weight gain. A transformation in gut microbiota has been demonstrated in patients who have undergone bariatric surgery which has been positively associated with post-surgical weight loss. However, there is lack of studies investigating the impact of probiotics on weight loss in post-bariatric surgery patients. The objectives of our study were to investigate the impact of a probiotic, Lactobacillus GG (LGG), on weight loss and quality of life in patients who have undergone bariatric surgery. Methods: The study was registered with ClinicalTrials.gov NCT01870544. Subjects were randomized to receive either LGG or placebo capsules. Percent total weight loss at their post-operative visits was calculated and differences between the two groups were tested using a t-test with unequal variances. The effect of LGG on Gastrointestinal Quality of Life Index (GIQLI) scores was estimated using a mixed model repeated measures model. Results: The mean rate of change in percent total weight loss at the ‘30-day’ post-operative visit for the placebo and treatment groups was 0.098 and 0.079 (p = 0.41), respectively, whereas that at the ‘90-day’ post-operative visit was 0.148 and 0.126 (p = 0.18), respectively. The difference in GIQLI scores on ’30-day’ and ’90-day’ visits were 0.5 (-7.1, 8.0), p=0.91 and 3.7 (-4.9, 12.3), p=0.42, respectively. LGG was recovered from the stools of 3 out of 5 subjects in the treatment group.. Conclusion: We did not appreciate a significant difference in the mean rate of weight loss or GIQLI scores between the groups who received LGG versus placebo. This study demonstrated survival of lactobacillus during transit through the gastrointestinal tract.
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