通过降低胆固醇促进健康：是否存在不可预见的风险？

IF 3.6 2区心理学 Q1 PSYCHOLOGY, MULTIDISCIPLINARY

Annals of Behavioral Medicine Pub Date : 2024-03-27 DOI:10.1093/abm/14.2.101

Matthew F. Muldoon, Stephen B. Manuck

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引用次数: 0

摘要

虽然大量科学证据证明了未经治疗的高胆固醇血症的风险，但长期降低胆固醇也可能与不良健康影响有关。本文讨论了降低血清胆固醇水平与以下三种特定不良后果之间的潜在联系：（a）癌症；（b）出血性中风；以及（c）非疾病相关原因（自杀、事故或暴力）导致的死亡。其中包括对血清胆固醇和膳食脂肪消耗量的流行病学研究数据，以及通过膳食或药物治疗降低胆固醇的随机临床试验证据。虽然有证据表明血清胆固醇的降低与这三种疾病或事件中的每一种都有关联，但由于现有证据的不一致性和局限性，目前还无法就降低胆固醇治疗的安全性或危险性得出结论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Health Through Cholesterol Reduction: Are there Unforeseen Risks?

While abundant scientific evidence documents the risks of untreated hypercholesterolemia, long-term cholesterol-lowering could also be associated with adverse health effects. This article discusses potential connections between reduced serum cholesterol levels and three specific adverse outcomes: (a) cancer, (b) hemorrhagic stroke, and(c) death from non-illness related causes (suicide, accident, or violence). Included are data from epidemiologic studies of both serum cholesterol and dietary fat consumption, and evidence from randomized, clinical trials of cholesterol lowering with either dietary or pharmacologic treatment. While some evidence links reduced serum cholesterol with each of these three illnesses or events, the inconsistencies and limitations of the available evidence presently preclude conclusions regarding either the safety or dangers of cholesterol-lowering treatments.

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来源期刊

Annals of Behavioral Medicine PSYCHOLOGY, MULTIDISCIPLINARY-

CiteScore

7.00

自引率

5.30%

发文量

期刊介绍： Annals of Behavioral Medicine aims to foster the exchange of knowledge derived from the disciplines involved in the field of behavioral medicine, and the integration of biological, psychosocial, and behavioral factors and principles as they relate to such areas as health promotion, disease prevention, risk factor modification, disease progression, adjustment and adaptation to physical disorders, and rehabilitation. To achieve these goals, much of the journal is devoted to the publication of original empirical articles including reports of randomized controlled trials, observational studies, or other basic and clinical investigations. Integrative reviews of the evidence for the application of behavioral interventions in health care will also be provided. .