{"title":"肾上腺素能激动剂与胰岛素对灌注大鼠心脏3- o -甲基- d -葡萄糖外排及肌层细胞松弛素B结合影响的比较。","authors":"K C Abel, S Rattigan, M G Clark","doi":"10.1016/0020-711x(88)90353-9","DOIUrl":null,"url":null,"abstract":"<p><p>1. alpha- and beta-Adrenergic agonists as well as insulin stimulate 3-O-methyl-D-glucose efflux by the perfused rat heart and increase D-glucose inhibitable cytochalasin B binding by isolated sarcolemma. 2. alpha- and beta-Agonists like insulin increase Vmax for 3-O-methyl-D-glucose efflux and increase Bmax for cytochalasin B binding. 3. The effects of alpha- and beta-agonists are totally Ca2+-dependent whilst those of insulin appear to be only partly Ca2+-dependent.</p>","PeriodicalId":22539,"journal":{"name":"The International journal of biochemistry","volume":"20 3","pages":"291-5"},"PeriodicalIF":0.0000,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0020-711x(88)90353-9","citationCount":"2","resultStr":"{\"title\":\"Comparison of adrenergic agonist and insulin effects on 3-O-methyl-D-glucose efflux and sarcolemmal cytochalasin B binding by perfused rat heart.\",\"authors\":\"K C Abel, S Rattigan, M G Clark\",\"doi\":\"10.1016/0020-711x(88)90353-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>1. alpha- and beta-Adrenergic agonists as well as insulin stimulate 3-O-methyl-D-glucose efflux by the perfused rat heart and increase D-glucose inhibitable cytochalasin B binding by isolated sarcolemma. 2. alpha- and beta-Agonists like insulin increase Vmax for 3-O-methyl-D-glucose efflux and increase Bmax for cytochalasin B binding. 3. The effects of alpha- and beta-agonists are totally Ca2+-dependent whilst those of insulin appear to be only partly Ca2+-dependent.</p>\",\"PeriodicalId\":22539,\"journal\":{\"name\":\"The International journal of biochemistry\",\"volume\":\"20 3\",\"pages\":\"291-5\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1988-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0020-711x(88)90353-9\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The International journal of biochemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/0020-711x(88)90353-9\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The International journal of biochemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/0020-711x(88)90353-9","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
摘要
1. -和-肾上腺素能激动剂以及胰岛素刺激灌注大鼠心脏的3- o -甲基- d -葡萄糖外排，并增加d -葡萄糖抑制细胞松弛素B与分离的肌膜的结合。2. -和-激动剂如胰岛素增加3- o -甲基- d -葡萄糖外排的Vmax和增加细胞松弛素B结合的Bmax。3.α和β激动剂的作用完全依赖于Ca2+，而胰岛素的作用似乎只是部分依赖于Ca2+。
Comparison of adrenergic agonist and insulin effects on 3-O-methyl-D-glucose efflux and sarcolemmal cytochalasin B binding by perfused rat heart.
1. alpha- and beta-Adrenergic agonists as well as insulin stimulate 3-O-methyl-D-glucose efflux by the perfused rat heart and increase D-glucose inhibitable cytochalasin B binding by isolated sarcolemma. 2. alpha- and beta-Agonists like insulin increase Vmax for 3-O-methyl-D-glucose efflux and increase Bmax for cytochalasin B binding. 3. The effects of alpha- and beta-agonists are totally Ca2+-dependent whilst those of insulin appear to be only partly Ca2+-dependent.
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