探索作为人类间充质干细胞神经发生媒介的硫酸肝素蛋白多糖。

IF 3.6 4区 医学 Q3 CELL BIOLOGY
Sofia I Petersen, Rachel K Okolicsanyi, Larisa M Haupt
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引用次数: 0

摘要

阿尔茨海默病(AD)和创伤性脑损伤(TBI)是全球主要的公共卫生问题,每年有超过 3,800 万人患有阿尔茨海默病,约 4,800 万人(2,700 万至 6,900 万人)经历创伤性脑损伤。神经退行性疾病的特征是神经毒性淀粉样蛋白 beta(Aβ)和微管相关蛋白 Tau(Tau)的积累,目前的治疗方法侧重于控制症状,而不是解决根本原因。硫酸肝素蛋白多糖(HSPGs)是一个多样化的大分子家族,可与各种蛋白质和配体相互作用,促进神经发生,即从干细胞形成新神经细胞的过程。辛迪康(SDC)和甘丙吡康(GPC)HSPGs与注意力缺失症的发病机制有关,是疾病的驱动因素,也是潜在的治疗靶点。人类间充质干细胞(hMSCs)由于其相对容易分离和随后广泛的体外扩展潜力,为研究和潜在治疗神经退行性疾病提供了一个有吸引力的治疗选择。HSPG是神经退行性疾病的一个关键特征,了解HSPG如何调节蛋白质聚集对于揭示AD和TBI的潜在疾病过程以及这两种神经系统疾病之间的任何联系至关重要。进一步的研究可能会验证 HSPG(特别是 SDC 或 GPC)作为神经退行性疾病靶点的用途,无论是通过驱动 hMSC 干细胞疗法还是直接靶向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Exploring Heparan Sulfate Proteoglycans as Mediators of Human Mesenchymal Stem Cell Neurogenesis.

Exploring Heparan Sulfate Proteoglycans as Mediators of Human Mesenchymal Stem Cell Neurogenesis.

Alzheimer's disease (AD) and traumatic brain injury (TBI) are major public health issues worldwide, with over 38 million people living with AD and approximately 48 million people (27-69 million) experiencing TBI annually. Neurodegenerative conditions are characterised by the accumulation of neurotoxic amyloid beta (Aβ) and microtubule-associated protein Tau (Tau) with current treatments focused on managing symptoms rather than addressing the underlying cause. Heparan sulfate proteoglycans (HSPGs) are a diverse family of macromolecules that interact with various proteins and ligands and promote neurogenesis, a process where new neural cells are formed from stem cells. The syndecan (SDC) and glypican (GPC) HSPGs have been implicated in AD pathogenesis, acting as drivers of disease, as well as potential therapeutic targets. Human mesenchymal stem cells (hMSCs) provide an attractive therapeutic option for studying and potentially treating neurodegenerative diseases due to their relative ease of isolation and subsequent extensive in vitro expansive potential. Understanding how HSPGs regulate protein aggregation, a key feature of neurodegenerative disorders, is essential to unravelling the underlying disease processes of AD and TBI, as well as any link between these two neurological disorders. Further research may validate HSPG, specifically SDCs or GPCs, use as neurodegenerative disease targets, either via driving hMSC stem cell therapy or direct targeting.

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来源期刊
CiteScore
7.70
自引率
0.00%
发文量
137
审稿时长
4-8 weeks
期刊介绍: Cellular and Molecular Neurobiology publishes original research concerned with the analysis of neuronal and brain function at the cellular and subcellular levels. The journal offers timely, peer-reviewed articles that describe anatomic, genetic, physiologic, pharmacologic, and biochemical approaches to the study of neuronal function and the analysis of elementary mechanisms. Studies are presented on isolated mammalian tissues and intact animals, with investigations aimed at the molecular mechanisms or neuronal responses at the level of single cells. Cellular and Molecular Neurobiology also presents studies of the effects of neurons on other organ systems, such as analysis of the electrical or biochemical response to neurotransmitters or neurohormones on smooth muscle or gland cells.
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