{"title":"室温下无金属和碱条件下的喹喔啉酮芳基化反应","authors":"","doi":"10.1007/s00706-024-03188-2","DOIUrl":null,"url":null,"abstract":"<h3>Abstract</h3> <p>A mild and efficient method for the arylation of quinoxalinones are described using aryldiazonium tetrafluoroborates as aryl source. Reactions proceeds at room temperature in a short reaction time of 1 h without metal catalysts and bases. Broad functional group tolerance was observed with good yields of products even at gram scale reaction. Control experiments suggest that the reactions proceed through a radical pathway. Furthermore, the present protocol applied for the successive synthesis of three biologically active molecules. Overall, the method offers a convenient and versatile approach for the synthesis of arylated quinoxalinones.</p> <span> <h3>Graphical abstract</h3> <p> <span> <span> <img alt=\"\" src=\"https://static-content.springer.com/image/MediaObjects/706_2024_3188_Figa_HTML.png\"/> </span> </span></p> </span>","PeriodicalId":19011,"journal":{"name":"Monatshefte für Chemie / Chemical Monthly","volume":"66 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Arylation of quinoxalinones at room temperature under metal and base free-conditions\",\"authors\":\"\",\"doi\":\"10.1007/s00706-024-03188-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3>Abstract</h3> <p>A mild and efficient method for the arylation of quinoxalinones are described using aryldiazonium tetrafluoroborates as aryl source. Reactions proceeds at room temperature in a short reaction time of 1 h without metal catalysts and bases. Broad functional group tolerance was observed with good yields of products even at gram scale reaction. Control experiments suggest that the reactions proceed through a radical pathway. Furthermore, the present protocol applied for the successive synthesis of three biologically active molecules. Overall, the method offers a convenient and versatile approach for the synthesis of arylated quinoxalinones.</p> <span> <h3>Graphical abstract</h3> <p> <span> <span> <img alt=\\\"\\\" src=\\\"https://static-content.springer.com/image/MediaObjects/706_2024_3188_Figa_HTML.png\\\"/> </span> </span></p> </span>\",\"PeriodicalId\":19011,\"journal\":{\"name\":\"Monatshefte für Chemie / Chemical Monthly\",\"volume\":\"66 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-03-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Monatshefte für Chemie / Chemical Monthly\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s00706-024-03188-2\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Monatshefte für Chemie / Chemical Monthly","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s00706-024-03188-2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Arylation of quinoxalinones at room temperature under metal and base free-conditions
Abstract
A mild and efficient method for the arylation of quinoxalinones are described using aryldiazonium tetrafluoroborates as aryl source. Reactions proceeds at room temperature in a short reaction time of 1 h without metal catalysts and bases. Broad functional group tolerance was observed with good yields of products even at gram scale reaction. Control experiments suggest that the reactions proceed through a radical pathway. Furthermore, the present protocol applied for the successive synthesis of three biologically active molecules. Overall, the method offers a convenient and versatile approach for the synthesis of arylated quinoxalinones.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
