Celastrol 可通过抑制炎症细胞因子反应限制实验性牙周炎相关牙槽骨流失。

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL
BioMedicine-Taiwan Pub Date : 2023-12-01 eCollection Date: 2023-01-01 DOI:10.37796/2211-8039.1421
Ahmet Altın, Meltem Zihni Korkmaz, Mehtap Atak, Tolga Mercantepe, Hülya Kılıç Yılmaz
{"title":"Celastrol 可通过抑制炎症细胞因子反应限制实验性牙周炎相关牙槽骨流失。","authors":"Ahmet Altın, Meltem Zihni Korkmaz, Mehtap Atak, Tolga Mercantepe, Hülya Kılıç Yılmaz","doi":"10.37796/2211-8039.1421","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Periodontitis is a common chronic inflammatory disease characterized by the destruction of the supporting structures of the teeth. The host defense mechanisms are responsible for inflamatuar and destructive reactions in periodontitis. Celastrol is one of the most promising components of the plant in Eastern and Southern China that has a long history of use in traditional medicine for the treatment of inflammatory conditions.</p><p><strong>Aim: </strong>The aim of this animal study was to inspect the preventive or restrictive effects of celastrol on periodontitis-related inflammatory host response and alveolar bone loss.</p><p><strong>Methods: </strong>24 male Sprague Dawley rats were randomly assigned into 3 groups: control, experimental periodontitis (Ep), and experimental periodontitis-celastrol (Ep-Cel). Periodontitis was induced by placing ligatures sub-paramarginally around the mandibular first molars of the rats in the Ep and Ep-Cel groups and maintaining the ligatures for 15 days. For 14 days following the ligature placement, celastrol administration (1 mg/kg BW day) for the Ep-Cel group and vehicle injection for the control and Ep groups was carried out. At the end of the experiment, mandibula and gingiva samples were obtained after the euthanasia. Alveolar bone loss was measured on serial histological slices; Tumor Necrosis Factor-α and Interleukin-1β levels were measured on gingiva samples by ELISA.</p><p><strong>Results: </strong>Systemic celastrol administration significantly restricted the alveolar bone loss that was higher in rats with periodontitis. (p < 0.05) Tumor Necrosis Factor-α and Interleukin-1β levels that were high in the gingiva of the rats with periodontitis were found significantly lower in rats administered celastrol. (p < 0.05).</p><p><strong>Conclusion: </strong>Celastrol restricted periodontitis-related alveolar bone loss by suppressing the inflammatory response.</p>","PeriodicalId":51650,"journal":{"name":"BioMedicine-Taiwan","volume":null,"pages":null},"PeriodicalIF":2.1000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10962540/pdf/","citationCount":"0","resultStr":"{\"title\":\"Celastrol restricts experimental periodontitis related alveolar bone loss by suppressing inflammatory cytokine response.\",\"authors\":\"Ahmet Altın, Meltem Zihni Korkmaz, Mehtap Atak, Tolga Mercantepe, Hülya Kılıç Yılmaz\",\"doi\":\"10.37796/2211-8039.1421\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Periodontitis is a common chronic inflammatory disease characterized by the destruction of the supporting structures of the teeth. The host defense mechanisms are responsible for inflamatuar and destructive reactions in periodontitis. Celastrol is one of the most promising components of the plant in Eastern and Southern China that has a long history of use in traditional medicine for the treatment of inflammatory conditions.</p><p><strong>Aim: </strong>The aim of this animal study was to inspect the preventive or restrictive effects of celastrol on periodontitis-related inflammatory host response and alveolar bone loss.</p><p><strong>Methods: </strong>24 male Sprague Dawley rats were randomly assigned into 3 groups: control, experimental periodontitis (Ep), and experimental periodontitis-celastrol (Ep-Cel). Periodontitis was induced by placing ligatures sub-paramarginally around the mandibular first molars of the rats in the Ep and Ep-Cel groups and maintaining the ligatures for 15 days. For 14 days following the ligature placement, celastrol administration (1 mg/kg BW day) for the Ep-Cel group and vehicle injection for the control and Ep groups was carried out. At the end of the experiment, mandibula and gingiva samples were obtained after the euthanasia. Alveolar bone loss was measured on serial histological slices; Tumor Necrosis Factor-α and Interleukin-1β levels were measured on gingiva samples by ELISA.</p><p><strong>Results: </strong>Systemic celastrol administration significantly restricted the alveolar bone loss that was higher in rats with periodontitis. (p < 0.05) Tumor Necrosis Factor-α and Interleukin-1β levels that were high in the gingiva of the rats with periodontitis were found significantly lower in rats administered celastrol. (p < 0.05).</p><p><strong>Conclusion: </strong>Celastrol restricted periodontitis-related alveolar bone loss by suppressing the inflammatory response.</p>\",\"PeriodicalId\":51650,\"journal\":{\"name\":\"BioMedicine-Taiwan\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2023-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10962540/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BioMedicine-Taiwan\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.37796/2211-8039.1421\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BioMedicine-Taiwan","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37796/2211-8039.1421","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0

摘要

简介牙周炎是一种常见的慢性炎症性疾病,其特点是牙齿的支撑结构遭到破坏。牙周炎的炎症和破坏性反应是由宿主防御机制引起的。方法:将 24 只雄性 Sprague Dawley 大鼠随机分为 3 组:对照组、实验性牙周炎组(Ep)和实验性牙周炎-青霉烯醇组(Ep-Cel)。通过在 Ep 组和 Ep-Cel 组大鼠的下颌第一臼齿近旁放置结扎线诱发牙周炎,并将结扎线保持 15 天。在结扎后的 14 天内,对 Ep-Cel 组大鼠注射西司他醇(每天 1 毫克/千克体重),对对照组和 Ep 组大鼠注射药物。实验结束时,在安乐死后采集下颌骨和牙龈样本。在连续组织切片上测量牙槽骨损失;用酶联免疫吸附法测定牙龈样本中肿瘤坏死因子-α和白细胞介素-1β的水平:结果:全身服用西司他醇可明显减少牙周炎大鼠的牙槽骨损失,而牙周炎大鼠的牙槽骨损失更高。(p < 0.05) 患有牙周炎的大鼠牙龈中肿瘤坏死因子-α和白细胞介素-1β水平较高,而服用西司他醇的大鼠牙龈中肿瘤坏死因子-α和白细胞介素-1β水平明显降低(p < 0.05)。(p < 0.05):塞拉司醇通过抑制炎症反应限制了牙周炎相关的牙槽骨流失。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Celastrol restricts experimental periodontitis related alveolar bone loss by suppressing inflammatory cytokine response.

Introduction: Periodontitis is a common chronic inflammatory disease characterized by the destruction of the supporting structures of the teeth. The host defense mechanisms are responsible for inflamatuar and destructive reactions in periodontitis. Celastrol is one of the most promising components of the plant in Eastern and Southern China that has a long history of use in traditional medicine for the treatment of inflammatory conditions.

Aim: The aim of this animal study was to inspect the preventive or restrictive effects of celastrol on periodontitis-related inflammatory host response and alveolar bone loss.

Methods: 24 male Sprague Dawley rats were randomly assigned into 3 groups: control, experimental periodontitis (Ep), and experimental periodontitis-celastrol (Ep-Cel). Periodontitis was induced by placing ligatures sub-paramarginally around the mandibular first molars of the rats in the Ep and Ep-Cel groups and maintaining the ligatures for 15 days. For 14 days following the ligature placement, celastrol administration (1 mg/kg BW day) for the Ep-Cel group and vehicle injection for the control and Ep groups was carried out. At the end of the experiment, mandibula and gingiva samples were obtained after the euthanasia. Alveolar bone loss was measured on serial histological slices; Tumor Necrosis Factor-α and Interleukin-1β levels were measured on gingiva samples by ELISA.

Results: Systemic celastrol administration significantly restricted the alveolar bone loss that was higher in rats with periodontitis. (p < 0.05) Tumor Necrosis Factor-α and Interleukin-1β levels that were high in the gingiva of the rats with periodontitis were found significantly lower in rats administered celastrol. (p < 0.05).

Conclusion: Celastrol restricted periodontitis-related alveolar bone loss by suppressing the inflammatory response.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
BioMedicine-Taiwan
BioMedicine-Taiwan MEDICINE, GENERAL & INTERNAL-
CiteScore
2.80
自引率
5.90%
发文量
21
审稿时长
24 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信