CXCL11 及其受体在癌症中的作用：前瞻性但极具挑战性的临床靶点

IF 2.5 4区医学 Q3 ONCOLOGY

Cancer Control Pub Date : 2024-01-01 DOI:10.1177/10732748241241162

Jiaqi Wang, Xinting Ouyang, Weijian Zhu, Qiang Yi, Jinghua Zhong

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引用次数: 0

摘要

趋化因子配体 11 是 CXC 趋化因子家族的成员，主要通过与 CXCR3 和 CXCR7 结合发挥其生物学功能。CXCL11 基因在各种人类恶性肿瘤中普遍过表达，但其具体机制因癌症类型而异。最近的研究发现，CXCL11 参与多种致癌信号通路的激活，与肿瘤的发生、发展、化疗耐受性、免疫疗法疗效和预后不良密切相关。根据其受体亚型的特定表达，CXCL11 在肿瘤中还具有复杂的两重作用；因此，直接靶向 CXCL11 及其受体的结构-功能可能是一项具有挑战性的任务。在这篇综述中，我们总结了 CXCL11 及其受体的生物学功能及其在各类恶性肿瘤中的作用，并指出了临床应用的方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Role of CXCL11 and its Receptors in Cancer: Prospective but Challenging Clinical Targets.

Chemokine ligand 11 is a member of the CXC chemokine family and exerts its biological function mainly through binding to CXCR3 and CXCR7. The CXCL11 gene is ubiquitously overexpressed in various human malignant tumors; however, its specific mechanisms vary among different cancer types. Recent studies have found that CXCL11 is involved in the activation of multiple oncogenic signaling pathways and is closely related to tumorigenesis, progression, chemotherapy tolerance, immunotherapy efficacy, and poor prognosis. Depending on the specific expression of its receptor subtype, CXCL11 also has a complex 2-fold role in tumours; therefore, directly targeting the structure-function of CXCL11 and its receptors may be a challenging task. In this review, we summarize the biological functions of CXCL11 and its receptors and their roles in various types of malignant tumors and point out the directions for clinical applications.

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来源期刊

Cancer Control ONCOLOGY-

CiteScore

3.80

自引率

0.00%

发文量

148

审稿时长

>12 weeks

期刊介绍： Cancer Control is a JCR-ranked, peer-reviewed open access journal whose mission is to advance the prevention, detection, diagnosis, treatment, and palliative care of cancer by enabling researchers, doctors, policymakers, and other healthcare professionals to freely share research along the cancer control continuum. Our vision is a world where gold-standard cancer care is the norm, not the exception.