实验性肥胖和吸烟条件下肺组织的超微结构变化

IF 1.2 4区 医学 Q4 DEVELOPMENTAL BIOLOGY
Yuliia Kuzyk, Olena Mazur, Yuryj Bisyarin
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引用次数: 0

摘要

肥胖会导致呼吸系统疾病,因为脂肪组织堆积和脂肪细胞产生大量细胞因子。首先,吸烟与多种肺部疾病有关,其特点是肺组织弥漫性变化和肺呼吸量减少。本研究旨在调查实验性肥胖和吸烟条件下性成熟雄性大鼠肺部的超微结构变化。实验动物样本共 120 只,分为四组:对照组(30 只)--以标准饮食喂养的条件健康大鼠;单独暴露于烟草烟雾的大鼠组(30 只);实验性肥胖大鼠组(30 只)和同时暴露于烟草烟雾的实验性肥胖大鼠组(30 只)--以高脂肪饮食喂养并暴露于烟草烟雾室。实验性肥胖大鼠组和同时暴露于烟草烟雾的实验性肥胖大鼠组所显示的肺部超微结构特征没有质的差异,这表明无论被动吸烟是否对肺组织产生直接的破坏作用,肺组织的超微结构都会发生病理变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ultrastructural changes of lung tissue under conditions of experimental obesity and smoking.

Obesity can cause respiratory disorders inflicted by adipose tissue accumulation and the numerous cytokines adipocytes produce. Smoking is, first of all, associated with a wide range of lung diseases characterized by diffuse changes in the lung tissue and a decrease in the respiratory volume of the lungs. The study aimed to investigate the ultrastructural changes in the lungs of sexually mature male rats under conditions of experimental obesity and smoking. The total sample of experimental animals consisted of 120 rats, divided into four groups: the control group (n=30) - conditionally healthy rats fed on a standard diet; a group of rats subjected to isolated exposure to tobacco smoke (n=30); a group of experimentally obese rats (n=30) and a group of experimentally obese rats simultaneously exposed to tobacco smoke (n=30) - feeding using a high-fat diet with exposure to a chamber with tobacco smoke. The revealed ultrastructural features of the lungs in the group of rats with experimental obesity and the group of rats with experimental obesity that were simultaneously exposed to tobacco smoke did not differ qualitatively, which indicates that pathological changes in the ultrastructure of the lung tissue developed regardless of the presence or absence of a direct damaging effect on the lung tissue of passive smoking.

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来源期刊
CiteScore
1.70
自引率
20.00%
发文量
221
审稿时长
3-8 weeks
期刊介绍: Romanian Journal of Morphology and Embryology (Rom J Morphol Embryol) publishes studies on all aspects of normal morphology and human comparative and experimental pathology. The Journal accepts only researches that utilize modern investigation methods (studies of anatomy, pathology, cytopathology, immunohistochemistry, histochemistry, immunology, morphometry, molecular and cellular biology, electronic microscopy, etc.).
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