用于评估植入式心血管设备和生物组织的系统模拟循环环路回顾。

IF 1.5 2区 医学 Q3 PERIPHERAL VASCULAR DISEASE
Journal of Endovascular Therapy Pub Date : 2025-10-01 Epub Date: 2024-03-25 DOI:10.1177/15266028241235876
Emmanouil Agrafiotis, Daniel Zimpfer, Heinrich Mächler, Gerhard A Holzapfel
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引用次数: 0

摘要

临床影响:在心血管模拟器中对植入式设备或组织/器官进行基于需求的体外监测,可为设备原型提供新的见解并铺平新的道路。所获得的见解不仅能满足患者的需求,还能让工程师、科学家和临床医生了解疾病(在常规监测期间)尚未发现的方面。我们分析了开创性的工作和当前的工作,并强调了开发临床前工具的各种机会,这些工具将改善未来植入式设备的策略。从整体上看,模拟循环回路研究可以弥补体内和体外方法以及临床和实验室环境之间的差距,实现互利共赢。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Review of Systemic Mock Circulation Loops for Evaluation of Implantable Cardiovascular Devices and Biological Tissues.

Implantable cardiovascular devices must undergo evaluation prior to animal testing and clinical trials to ensure their performance and efficiency. Mock circulation loops (MCLs) are on-demand tools capable of reproducing physiological conditions in vivo and are also devices for preventative testing. Recognition of their success as useful tools comes from the fact that over 100 MCLs have been submitted for device assessment in recent years. Mock circulation loops could detect malfunctions that patients might otherwise experience. Thus, MCLs can complement preclinical and prototype evaluation rather than being mutually exclusive. In this review, we emphasize the experimental value of MCLs while providing a brief overview of the history of the field. In addition, the necessary hemodynamic parameters are analyzed to reproduce physiological scenarios in vitro. We also discuss the relevant setups when evaluating devices to assist heart failure and aortic pathologies, namely artificial hearts, left ventricular assist devices, stent-grafts, and artificial heart valves. Finally, we report novel setups developed to evaluate soft biological tissues for translational research.Clinical ImpactOn needs-based ex vivo monitoring of implantable devices or tissues/organs in cardiovascular simulators provides new insights and paves new paths for device prototypes. The insights gained could not only support the needs of patients, but also inform engineers, scientists and clinicians about undiscovered aspects of diseases (during routine monitoring). We analyze seminal and current work and highlight a variety of opportunities for developing preclinical tools that would improve strategies for future implantable devices. Holistically, mock circulation loop studies can bridge the gap between in vivo and in vitro approaches, as well as clinical and laboratory settings, in a mutually beneficial manner.

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来源期刊
CiteScore
5.30
自引率
15.40%
发文量
203
审稿时长
6-12 weeks
期刊介绍: The Journal of Endovascular Therapy (formerly the Journal of Endovascular Surgery) was established in 1994 as a forum for all physicians, scientists, and allied healthcare professionals who are engaged or interested in peripheral endovascular techniques and technology. An official publication of the International Society of Endovascular Specialists (ISEVS), the Journal of Endovascular Therapy publishes peer-reviewed articles of interest to clinicians and researchers in the field of peripheral endovascular interventions.
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