透明细胞肉瘤与带有 EWS 融合的颌骨和唾液腺肿瘤的比较。

IF 3.2 Q2 PATHOLOGY
Ornela Xhori, Navkiran Deol, Camron M Rivera, Jason Zavras, Sophia G Weil, Hirad Zafari, Julia C Thierauf, William C Faquin, Edwin Choy, Miguel N Rivera, A John Iafrate, Alexandre Jaquinet, Maria J Troulis
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引用次数: 0

摘要

目的:回顾被认定为 "透明细胞肉瘤 "的肿瘤,以确定其与罕见的EWS融合阳性颌骨和唾液腺肿瘤透明细胞牙原性癌(CCOC)和唾液腺透明细胞癌(CCC)的相似性:方法:使用 PubMed 收集所有关于透明细胞肉瘤(CCS)的报告。搜索参数为 "透明细胞肉瘤 "和 "CCS"。对出版物中的参考文献进行筛选和交叉引用。提取的数据包括人口统计学特征、症状和体征、放射学检查结果、组织学和免疫组化特征以及已知的分子/遗传畸变:结果:透明细胞肉瘤与 CCOC 和 CCC 有几处相似之处。这三种肿瘤类型都有相似的组织学表现,包括透明细胞的存在,以及相似的遗传特征,即都携带 EWSR1-CREB 家族融合。此外,这些肿瘤可出现在软组织和骨骼中,而且临床病程较长。CCS可出现在身体的任何部位,包括头颈部。这三种肿瘤似乎都偏爱女性,但与 CCOC 和 CCC 相比,CCS 的发病年龄可能略低(分别为第 3 个 10 年和第 5 个 10 年):结论:更好地了解这三种肿瘤的异同可能有助于更好地理解每一种肿瘤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Comparison of Clear Cell Sarcoma to Jaw and Salivary Tumors Bearing EWS Fusions.

Objective: To review tumors identified as "clear cell sarcoma" in order to determine similarities to the rare EWS fusion positive jaw and salivary gland tumors clear cell odontogenic carcinoma (CCOC) and clear cell carcinoma of the salivary gland (CCC).

Methods: PubMed was used to collect all reports of clear cell sarcoma (CCS). Search parameters were "clear cell sarcoma" and "CCS." References in the publications were screened and cross-referenced. Data extracted included demographic characteristics, presenting signs and symptoms, radiographic findings, histological and immunohistochemical features and known molecular/genetic aberrations.

Results: Clear cell sarcoma has several similarities to CCOC and CCC. All three tumor types have similar histologic appearances including the presence of clear cells, as well as similar genetic profiles in that all harbor an EWSR1-CREB family fusions. Additionally, these tumors appear in soft tissue as well as bone, and can have a prolonged clinical course. CCS can appear anywhere in the body, including the head and neck region. All three tumors appear to have a predilection to women, although CCS may have a slight younger age of onset as compared to CCOC and CCC (3rd vs 5th decade of life, respectively).

Conclusion: Gaining a better understanding of the similarities and differences between these three tumors may lead to a better understanding of each one.

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来源期刊
CiteScore
5.70
自引率
9.50%
发文量
99
期刊介绍: Head & Neck Pathology presents scholarly papers, reviews and symposia that cover the spectrum of human surgical pathology within the anatomic zones of the oral cavity, sinonasal tract, larynx, hypopharynx, salivary gland, ear and temporal bone, and neck. The journal publishes rapid developments in new diagnostic criteria, intraoperative consultation, immunohistochemical studies, molecular techniques, genetic analyses, diagnostic aids, experimental pathology, cytology, radiographic imaging, and application of uniform terminology to allow practitioners to continue to maintain and expand their knowledge in the subspecialty of head and neck pathology. Coverage of practical application to daily clinical practice is supported with proceedings and symposia from international societies and academies devoted to this field. Single-blind peer review The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.
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