Coral Perez González, Chandni Bardolia, Katie Pizzolato, Nishita Shah Amin
{"title":"利用药物基因组学结果改善他汀类药物相关的肌肉症状。","authors":"Coral Perez González, Chandni Bardolia, Katie Pizzolato, Nishita Shah Amin","doi":"10.4140/TCP.n.2024.151","DOIUrl":null,"url":null,"abstract":"<p><p>The objective of this aims to demonstrate the advantage of a pharmacogenomics (PGx)-informed medication review in mitigating adverse drug events (ADEs) and optimizing therapeutic outcomes. PGx testing and PGx-informed medication reviews assist in mitigating ADEs. PGx testing was performed on a 68-year-old male presenting with uncontrolled chronic pain. The PGx results highlighted a drug-gene interaction, aiding in identification of the increased risk of statin-associated muscle symptoms (SAMS) attributing to uncontrolled chronic pain. This patient case report illustrates how incorporating PGx results can help improve chronic pain and mitigate ADEs, such as SAMS.</p>","PeriodicalId":41635,"journal":{"name":"Senior Care Pharmacist","volume":"39 4","pages":"151-158"},"PeriodicalIF":0.0000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Utilizing Pharmacogenomics Results to Improve Statin-Associated Muscle Symptoms.\",\"authors\":\"Coral Perez González, Chandni Bardolia, Katie Pizzolato, Nishita Shah Amin\",\"doi\":\"10.4140/TCP.n.2024.151\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The objective of this aims to demonstrate the advantage of a pharmacogenomics (PGx)-informed medication review in mitigating adverse drug events (ADEs) and optimizing therapeutic outcomes. PGx testing and PGx-informed medication reviews assist in mitigating ADEs. PGx testing was performed on a 68-year-old male presenting with uncontrolled chronic pain. The PGx results highlighted a drug-gene interaction, aiding in identification of the increased risk of statin-associated muscle symptoms (SAMS) attributing to uncontrolled chronic pain. This patient case report illustrates how incorporating PGx results can help improve chronic pain and mitigate ADEs, such as SAMS.</p>\",\"PeriodicalId\":41635,\"journal\":{\"name\":\"Senior Care Pharmacist\",\"volume\":\"39 4\",\"pages\":\"151-158\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Senior Care Pharmacist\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4140/TCP.n.2024.151\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Senior Care Pharmacist","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4140/TCP.n.2024.151","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
Utilizing Pharmacogenomics Results to Improve Statin-Associated Muscle Symptoms.
The objective of this aims to demonstrate the advantage of a pharmacogenomics (PGx)-informed medication review in mitigating adverse drug events (ADEs) and optimizing therapeutic outcomes. PGx testing and PGx-informed medication reviews assist in mitigating ADEs. PGx testing was performed on a 68-year-old male presenting with uncontrolled chronic pain. The PGx results highlighted a drug-gene interaction, aiding in identification of the increased risk of statin-associated muscle symptoms (SAMS) attributing to uncontrolled chronic pain. This patient case report illustrates how incorporating PGx results can help improve chronic pain and mitigate ADEs, such as SAMS.
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