妊娠早期降低 INR 对子痫前期发生的影响:一项回顾性队列研究。

IF 2.3 4区 医学 Q2 HEMATOLOGY
Pei-Pei Jin, Ning Ding, Jing Dai, Xiao-Yan Liu, Pei-Min Mao
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引用次数: 0

摘要

目的:研究妊娠早期活化部分凝血酶原时间(APTT)、凝血酶原时间(PT)和国际标准化比值(INR)降低对子痫前期风险的影响。共纳入 8549 名单胎孕妇。以年龄、出生、孕前体重指数、纤维蛋白原(FBG)、凝血酶时间(TT)、D-二聚体(DD2)、抗凝血酶 III(ATIII)、纤维蛋白降解产物(FDP)为混杂因素,建立 APTT、PT 和 INR 的广义线性模型,得出 INR 降低时 PT 和 INR 的相对风险。在对混杂因素进行充分调整后,妊娠早期血浆 PT 结果每增加 1 秒,子痫前期的相对风险为 0.703;血浆 INR 结果每增加 0.1,子痫前期的相对风险为 0.767。如果 PT 值小于 P25 量级(P25:0.5%),则子痫前期的相对风险为 0.5%。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of Reduced INR in Early Pregnancy on the Occurrence of Preeclampsia: A Retrospective Cohort Study.

To investigate the effect of reduced early-pregnancy activated partial thrombin time (APTT), prothrombin time (PT), and international standardized ratio (INR) on the risk of preeclampsia. A total of 8549 pregnant women with singleton births were included. Early pregnancy APTT, PT, and INR levels, with age, birth, prepregnancy body mass index, fibrinogen (FBG), thrombin time (TT), D-dimer (DD2), antithrombin III (ATIII), fibrin degradation products (FDP) as confounders, generalized linear model of APTT, the relative risk of PT and INR when INR reduction. After adequate adjustment for confounders, the relative risk of preeclampsia was 0.703 for every 1 s increase in plasma PT results in early pregnancy, and for every 0.1 increase in plasma INR results, the relative risk of preeclampsia was 0.767. With a PT less than the P25 quantile (<11 s), the relative risk of preeclampsia was 1.328. The relative risk of preeclampsia at an INR less than the P25 quantile (<0.92) was 1.24. There was no statistical association between APTT on the risk of preeclampsia. The relative risk of preeclampsia is strongly associated with a decrease in PT and INR in early pregnancy. PT and INR in early pregnancy were a potential marker in the risk stratification of preeclampsia. Focusing on reduced PT and INR levels in early pregnancy can help to identify early pregnancies at risk for preeclampsia.

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来源期刊
CiteScore
4.40
自引率
3.40%
发文量
150
审稿时长
2 months
期刊介绍: CATH is a peer-reviewed bi-monthly journal that addresses the practical clinical and laboratory issues involved in managing bleeding and clotting disorders, especially those related to thrombosis, hemostasis, and vascular disorders. CATH covers clinical trials, studies on etiology, pathophysiology, diagnosis and treatment of thrombohemorrhagic disorders.
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