FAM151B 基因多态性对胡羊睾丸相关性状参数的影响

IF 1.6 3区 农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE
Li Zhang , Tingting Lu , Xiuxiu Weng , Wanhong Li , Xiangpeng Yue , Yu Feng
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引用次数: 0

摘要

序列相似性151家族成员B(FAM151B)基因家族广泛分布于动物体内。该基因家族编码的蛋白属于磷酸二酯酶超家族,起水解细胞内第二信使的作用,通过降解细胞内cAMP或cGMP含量影响睾丸中Sertoli细胞的增殖,从而影响睾丸的生精能力。本研究筛选了491只胡羊的FAM151B基因突变,以分析FAM151B基因多态性与睾丸性状和精子相关参数之间的关联。结果发现,FAM151B基因中存在一个同义突变(5:g.77976636 C>T),导致三种基因型,即CC、TT和TC,基因型频率分别为0.33、0.05和0.62。研究发现,该同义突变与睾丸重量、长睾丸周径、短睾丸周径、附睾重量和精子数量显著相关(p <0.05)。此外,与 TC 和 TT 基因型的个体相比,CC 基因型的个体具有明显的生殖能力优势。本研究表明,FAM151B基因可能在睾丸发育过程中发挥重要作用,其SNPs与睾丸参数和精子数量相关,为公羊早期选择提供了重要指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of polymorphisms in the FAM151B gene on testis-related trait parameters in Hu sheep

The family with sequence similarity 151 member B (FAM151B) gene family is widely distributed in animals. This gene family encodes proteins belonging to the phosphodiesterase superfamily which plays a role in hydrolyzing intracellular second messengers, and affects the proliferation of Sertoli cells in the testis by degrading intracellular cAMP or cGMP content, thereby affecting the sperm production capacity of the testis. In this study, mutations in the FAM151B gene were screened in 491 Hu sheep to analyze the association among FAM151B gene polymorphisms testicular traits, and sperm-related parameters. A synonymous mutation (5: g.77976636 C>T), was detected in FAM151B, resulting in three genotypes, namely, CC, TT, and TC, with genotypic frequencies of 0.33, 0.05, and 0.62, respectively. This synonymous mutation was found to be significantly correlated with testicular weight, long testicular circumference, short testicular circumference, epididymal weight, and sperm count (p <0.05). In addition, individuals with CC genotypes had significant reproductive performance advantages compared with those with TC and TT genotypes. The current study shows that the FAM151B gene may play important roles in testicular development, and its SNPs are associated with testicular parameters, and sperm count, which provides important indicators for ram selection at early stage.

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来源期刊
Small Ruminant Research
Small Ruminant Research 农林科学-奶制品与动物科学
CiteScore
3.10
自引率
11.10%
发文量
210
审稿时长
12.5 weeks
期刊介绍: Small Ruminant Research publishes original, basic and applied research articles, technical notes, and review articles on research relating to goats, sheep, deer, the New World camelids llama, alpaca, vicuna and guanaco, and the Old World camels. Topics covered include nutrition, physiology, anatomy, genetics, microbiology, ethology, product technology, socio-economics, management, sustainability and environment, veterinary medicine and husbandry engineering.
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