格鲍尔镇痛®喷雾剂对侵入性手术部位的微生物安全性评估

Ami Attali, Thomas Vander Woude, Mohamed Fayed, Katherine Nowak
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引用次数: 0

摘要

本研究旨在调查格鲍尔公司(Gebauer Company,俄亥俄州克利夫兰市)的 "镇痛易®"局部冷冻喷雾剂对皮肤部位消毒的影响,重点是手腕和下背部。主要目的是确定使用 "镇痛舒缓剂 "是否会影响这些部位的消毒,从而使其成为侵入性医疗程序中注射用利多卡因的合适替代品。 这项前瞻性、盲法对照研究在密歇根州底特律市的亨利福特医院进行。医院招募了健康的成年员工,并征得了他们的书面同意。在使用 ChloraPrep™ (BD,Franklin Lakes,NJ)和 "镇痛易 "治疗前后,分别从手腕和腰部部位采集拭子。进行微生物培养,并对微生物生长水平进行评估和分类。数据分析包括比较未处理样本、ChloraPrep 处理样本和 ChloraPrep + Pain Ease 处理样本之间的微生物生长情况。 共收集了 72 位参与者的数据,每位参与者 6 份样本(2 个位置,每个位置 3 次治疗)。在手腕样本中,ChloraPrep 和 ChloraPrep + 镇痛剂在微生物生长方面没有明显的统计学差异。同样,对于下背部样本,这两个治疗组的微生物生长情况也没有明显差异。 这项研究表明,在 ChloraPrep 消毒过的皮肤区域使用 Gebauer 镇痛舒缓剂不会对减少细菌量产生负面影响,这支持了它在血管通路或侵入性医疗程序中替代注射用利多卡因和其他表层麻醉剂的潜力。不过,还需要进行进一步的研究,以探索在各种临床情况下如何应用 "镇痛舒缓剂",并在时间较长和侵入性较强的手术中优化患者的舒适度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Microbial Safety Assessment of Gebauer’s Pain Ease® Spray on Invasive Procedural Sites
This study aimed to investigate the impact of Gebauer’s Pain Ease® (Gebauer Company, Cleveland, OH) topical refrigerant spray on the disinfection of skin sites, focusing on the volar wrist and lower back. The primary objective was to determine whether the application of Pain Ease would compromise the disinfection of these sites, potentially making it a suitable alternative to injectable lidocaine for invasive medical procedures. This prospective, blinded, controlled study was conducted at Henry Ford Hospital in Detroit, MI. Healthy adult hospital employees were recruited, and written consent was obtained. Swabs were taken from the volar wrist and lower back sites before and after treatment with ChloraPrep™ (BD, Franklin Lakes, NJ) and Pain Ease. Microbial cultures were performed, and microbial growth levels were assessed and categorized. Data analysis included comparisons of microbial growth between untreated samples, ChloraPrep-treated samples, and ChloraPrep + Pain Ease-treated samples. Data were collected from 72 participants, with 6 samples per participant (2 locations, 3 treatments each). For wrist samples, there were no statistically significant differences in microbial growth between ChloraPrep and ChloraPrep + Pain Ease. Similarly, for lower-back samples, microbial growth did not significantly differ between these 2 treatment groups. This study demonstrates that the application of Gebauer’s Pain Ease to ChloraPrep disinfected skin areas does not negatively affect the reduction of the bacterial load, supporting its potential as an alternative to injectable lidocaine and other superficial anesthetics for vascular access or invasive medical procedures. However, further research is warranted to explore the application of Pain Ease in various clinical scenarios and optimize patient comfort during longer and more invasive procedures.
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