{"title":"维生素 D 水平是否会影响哮喘儿童的用力呼气流量 25-75?","authors":"Veena Anand, S. Joseph, I. Yadev","doi":"10.4038/sljch.v53i1.10706","DOIUrl":null,"url":null,"abstract":"Background: Previous reports of association between vitamin D levels and pulmonary function based on forced expiratory volume in one second (FEV1) and ratio of FEV1 to forced vital capacity (FEV1/FVC) gave mixed results. Forced expiratory flow 25-75 (FEF 25-75) is considered a sensitive parameter in children as it is effort independent.Objectives: To assess the correlation between serum vitamin D levels and pulmonary function parameters in children with asthma.Method: This cross-sectional analytic study was conducted at the paediatric respiratory clinic of a tertiary care referral hospital. Children aged 6-12 years, having asthma, on controllers with good compliance and under regular follow-up were enrolled.Results: Mean serum vitamin D level (16.8± 6.69ng/ml) was low and deficiency was seen in 36 (72%) children with asthma. Positive correlation (r=0.41) was seen between serum vitamin D levels and predicted FEF 25-75%. Univariate analysis between vitamin D and FEF 25-75 showed decreased vitamin D levels were associated with significantly low FEF 25-75 (p<0.001). In multivariate linear regression analysis after adjustment for age and sex, the relationship was direct and significant (R2=0.18, p<0.05) but for FEV1 the relationship was not significant (R2=-0.034, p=0.336).Conclusions: Vitamin D levels showed direct and significant relationship with FEF 25-75 outcome in children with asthma.","PeriodicalId":38870,"journal":{"name":"Sri Lanka Journal of Child Health","volume":"17 6","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Do vitamin D levels affect forced expiratory flow 25-75 among children with asthma?\",\"authors\":\"Veena Anand, S. Joseph, I. Yadev\",\"doi\":\"10.4038/sljch.v53i1.10706\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Previous reports of association between vitamin D levels and pulmonary function based on forced expiratory volume in one second (FEV1) and ratio of FEV1 to forced vital capacity (FEV1/FVC) gave mixed results. Forced expiratory flow 25-75 (FEF 25-75) is considered a sensitive parameter in children as it is effort independent.Objectives: To assess the correlation between serum vitamin D levels and pulmonary function parameters in children with asthma.Method: This cross-sectional analytic study was conducted at the paediatric respiratory clinic of a tertiary care referral hospital. Children aged 6-12 years, having asthma, on controllers with good compliance and under regular follow-up were enrolled.Results: Mean serum vitamin D level (16.8± 6.69ng/ml) was low and deficiency was seen in 36 (72%) children with asthma. Positive correlation (r=0.41) was seen between serum vitamin D levels and predicted FEF 25-75%. Univariate analysis between vitamin D and FEF 25-75 showed decreased vitamin D levels were associated with significantly low FEF 25-75 (p<0.001). In multivariate linear regression analysis after adjustment for age and sex, the relationship was direct and significant (R2=0.18, p<0.05) but for FEV1 the relationship was not significant (R2=-0.034, p=0.336).Conclusions: Vitamin D levels showed direct and significant relationship with FEF 25-75 outcome in children with asthma.\",\"PeriodicalId\":38870,\"journal\":{\"name\":\"Sri Lanka Journal of Child Health\",\"volume\":\"17 6\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-03-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Sri Lanka Journal of Child Health\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4038/sljch.v53i1.10706\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sri Lanka Journal of Child Health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4038/sljch.v53i1.10706","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
摘要
背景:以往关于维生素 D 水平与一秒钟用力呼气量(FEV1)和 FEV1 与用力肺活量之比(FEV1/FVC)的肺功能之间关系的报告结果不一。强制呼气流量 25-75 (FEF 25-75) 被认为是儿童的一个敏感参数,因为它与体力无关:评估哮喘患儿血清维生素 D 水平与肺功能参数之间的相关性:这项横断面分析研究在一家三级医疗转诊医院的儿科呼吸门诊进行。研究对象为年龄在 6-12 岁、患有哮喘、服用控制药物且依从性良好并接受定期随访的儿童:结果:平均血清维生素 D 水平(16.8± 6.69ng/ml)较低,36 名(72%)哮喘儿童缺乏维生素 D。血清维生素 D 水平与预测 FEF 25-75% 之间呈正相关(r=0.41)。维生素 D 和 FEF 25-75 之间的单变量分析表明,维生素 D 水平下降与 FEF 25-75 明显偏低有关(p<0.001)。在调整年龄和性别后的多变量线性回归分析中,两者关系直接且显著(R2=0.18,p<0.05),但与 FEV1 的关系不显著(R2=-0.034,p=0.336):维生素 D 水平与哮喘儿童的 FEF 25-75 结果有直接且显著的关系。
Do vitamin D levels affect forced expiratory flow 25-75 among children with asthma?
Background: Previous reports of association between vitamin D levels and pulmonary function based on forced expiratory volume in one second (FEV1) and ratio of FEV1 to forced vital capacity (FEV1/FVC) gave mixed results. Forced expiratory flow 25-75 (FEF 25-75) is considered a sensitive parameter in children as it is effort independent.Objectives: To assess the correlation between serum vitamin D levels and pulmonary function parameters in children with asthma.Method: This cross-sectional analytic study was conducted at the paediatric respiratory clinic of a tertiary care referral hospital. Children aged 6-12 years, having asthma, on controllers with good compliance and under regular follow-up were enrolled.Results: Mean serum vitamin D level (16.8± 6.69ng/ml) was low and deficiency was seen in 36 (72%) children with asthma. Positive correlation (r=0.41) was seen between serum vitamin D levels and predicted FEF 25-75%. Univariate analysis between vitamin D and FEF 25-75 showed decreased vitamin D levels were associated with significantly low FEF 25-75 (p<0.001). In multivariate linear regression analysis after adjustment for age and sex, the relationship was direct and significant (R2=0.18, p<0.05) but for FEV1 the relationship was not significant (R2=-0.034, p=0.336).Conclusions: Vitamin D levels showed direct and significant relationship with FEF 25-75 outcome in children with asthma.
期刊介绍:
This is the only journal of child health in Sri Lanka. It is designed to publish original research articles and scholarly articles by recognized authorities on paediatric subjects. It is distributed widely in Sri Lanka and bears the ISSN number 1391-5452 for the print issues and e-ISSN 2386-110x for the electronic version in the internet. The journal is published quarterly and the articles are reviewed by both local and foreign peers. The Journal is the primary organ of Continuing Paediatric Medical Education in Sri Lanka.