维生素 C 对对乙酰氨基酚引起的雄性大鼠肝脏和肾脏毒性的保护作用

S. Ebhohon, Ekene Victor Asoya, H. E. Iyare
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引用次数: 0

摘要

对乙酰氨基酚(扑热息痛)是一种广泛使用的非处方镇痛和解热药物,在推荐剂量内使用时以其疗效和安全性而闻名。然而,过量或长期使用对乙酰氨基酚会导致严重的肝毒性和肾毒性,从而引发重大的公共卫生问题。本研究旨在探讨维生素 C 对对乙酰氨基酚诱导的雄性 Wistar 大鼠肝毒性和肾毒性的保护作用。6 只大鼠被随机分配到 7 个组,第 1 组为对照组。第 2 组、第 4 组和第 6 组大鼠每天分别单次口服 100、200 和 400 毫克/千克对乙酰氨基酚。与此同时,第 3、5 和 7 组每天分别口服 100、200 和 400 毫克/千克对乙酰氨基酚,然后每天腹腔注射 100 毫克/千克维生素 C,连续 14 天。在评估肝功能指标(谷草转氨酶、谷丙转氨酶、总胆红素和总蛋白)和肾功能指标(尿素和肌酐水平)的同时,还通过抗氧化检测(SOD、CAT、GSH 和 MDA)评估了肝脏和肾脏组织的抗氧化状态。结果表明,维生素 C 对肝脏和肾脏组织具有保护作用,生化指标的变化也说明了这一点。这些研究结果表明,维生素 C 可在缓解不同剂量方案下对乙酰氨基酚引起的肝脏和肾脏损伤方面发挥关键作用,有可能成为预防或治疗药物引起的器官损伤的治疗干预措施。进一步的研究对于阐明维生素C作为对乙酰氨基酚毒性保护剂的潜在机制和验证其转化潜力至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
PROTECTIVE EFFECTS OF VITAMIN C ON ACETAMINOPHEN-INDUCED LIVER AND KIDNEY TOXICITY IN MALE RATS
Acetaminophen (paracetamol) is a widely used over-the-counter analgesic and antipyretic medication known for its efficacy and safety when administered within recommended doses. However, overdose or prolonged use of acetaminophen can lead to severe hepatotoxicity and nephrotoxicity, posing a significant public health concern. This study aims to investigate the protective effects of vitamin C on acetaminophen-induced hepatotoxicity and nephrotoxicity in male Wistar rats. Six rats were randomly assigned to seven groups, with Group 1 designated as the control. Groups 2, 4, and 6 were given daily single oral doses of 100, 200, and 400 mg/kg of acetaminophen, respectively. Meanwhile, Groups 3, 5, and 7 received daily single oral doses of 100, 200, and 400 mg/kg of acetaminophen, followed by intraperitoneal administration of 100 mg/kg of vitamin C daily, for 14 days. Liver function markers (AST, ALT, total bilirubin, and total protein) and renal function indicators (urea and creatinine levels) were assessed, alongside antioxidant status in liver and kidney tissues through antioxidant assays (SOD, CAT, GSH, and MDA). The results demonstrated the protective influence of vitamin C on liver and kidney tissues, as indicated by the modulation of biochemical markers. These findings suggest that vitamin C may play a pivotal role in alleviating acetaminophen-induced liver and kidney damage across different dosage regimens, potentially serving as a therapeutic intervention for preventing or treating drug-induced organ injuries. Further investigations are essential to elucidate the underlying mechanisms and validate the translational potential of vitamin C as a protective agent against acetaminophen toxicity.
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