Beyond Traditional Boundaries: A Review on Calotropis gigantea’s Efficacy in Wound Healing

Introduction: Wounds result from the disruption of cellular and anatomical continuity in living tissues due to external factors. Calotropis gigantea, also known as crown flower or giant milkweed (or "biduri" in Indonesia), is a small tree or shrub with white or purple flowers, widely used in traditional remedies. Its properties, including antimicrobial, cytotoxic, and wound-healing activities, have prompted this literature review to assess its efficacy in wound healing. Method: A thorough analysis of scientific findings and research conducted in the last 10 years, specifically after January 1, 2014, was undertaken. Data were collected from reputable databases, such as PubMed, Web of Science, and ScienceDirect. After applying publication limitations, three manuscripts were selected as the final outcomes of the review process. Result: The analysis of multiple studies reveals that C. gigantea possesses wound healing properties attributed to phytochemical constituents like flavonoids, tannins, alkaloids, and saponin. These constituents play vital roles in each stage of wound healing, including the inflammatory reaction, proliferation, and remodeling stages. Additionally, C. gigantea promotes wound healing, leaving minimal scar residues. Conclusion: Calotropis gigantea has demonstrated its ability to enhance wound healing through various mechanisms, including astringency, antibacterial activity, promotion of homeostasis, facilitation of collagen synthesis, enhancement of re-epithelialization, and stimulation of cell proliferation via its phytochemical constituents. However, due to the scarcity of recent studies, the plant's true efficacy in wound healing remains unclear.