{"title":"用绿色方法合成用于克诺文纳格尔缩合反应的磁性纳米颗粒及其功能化 MNPs","authors":"Raju Shekhanavar, S. Khatavi, Kantharaju Kamanna","doi":"10.2174/0122133372292087240228082859","DOIUrl":null,"url":null,"abstract":"\n\nKnoevenagel condensation is an important C-C bond formation reaction\ncatalyzed by various homogeneous and heterogeneous acid-base catalysts.\n\n\n\nKnoevenagel condensation is an important C-C bond formation reaction, and employs various acid and base-catalyzed reactions of both homogeneous and heterogeneous catalysts.\n\n\n\nThe present work describes the eco-friendly preparation of magnetic nanoparticles Fe3O4\n(MNPs) and its functionalization to Fe3O4@SiO2@SO3H. The prepared MNPs and their functionalized\nmaterials were fully characterized by FT-IR, XRD, FE-SEM, HR-TEM, and VSM. Further\ndemonstrated application of these catalysts for the C-C bond formation reactions of Knoevenagel\ncondensation employing special aldehyde derivatives with malononitrile at room temperature gave\nexcellent product isolation.\n\n\n\nThe application of the prepared functionalized MNPs for the Knoevenagel condensation\nwas demonstrated by the reaction of various aryl/heterocyclic and cholesterol aldehyde with malononitrile\nat room temperature stirring for about 30 min in ethanol solvent. The final product isolated\nis confirmed by various spectroscopic techniques such as FT-IR, 1H-, & 13C-NMR, and mass spectrometry.\nFurthermore, the selected compounds are screened for their photophysical properties, and\ninterestingly compound 3j showed good fluorescent properties.\n\n\n\nOverall the present work described a greener method preparation of MNPs, and its\nfunctionalized employed as a heterogeneous catalyst for the Knoevenagel condensation of various\naryl/heterocyclic and cholesterol aldehyde with malononitrile. The method developed is simple,\neasily separated catalyst by an external magnet, and recycled up to five cycles without any noticeable\nchange in the final product isolation. Further, the prepared derivatives screened for their photophysical\nproperties, and interestingly compound 3j showed good fluorescent properties.\n","PeriodicalId":10945,"journal":{"name":"Current Organocatalysis","volume":null,"pages":null},"PeriodicalIF":0.9000,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Green Method Synthesis of Magnetic Nanoparticles and its Functionalized MNPs for Knoevenagel Condensation Reaction\",\"authors\":\"Raju Shekhanavar, S. Khatavi, Kantharaju Kamanna\",\"doi\":\"10.2174/0122133372292087240228082859\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\\n\\nKnoevenagel condensation is an important C-C bond formation reaction\\ncatalyzed by various homogeneous and heterogeneous acid-base catalysts.\\n\\n\\n\\nKnoevenagel condensation is an important C-C bond formation reaction, and employs various acid and base-catalyzed reactions of both homogeneous and heterogeneous catalysts.\\n\\n\\n\\nThe present work describes the eco-friendly preparation of magnetic nanoparticles Fe3O4\\n(MNPs) and its functionalization to Fe3O4@SiO2@SO3H. The prepared MNPs and their functionalized\\nmaterials were fully characterized by FT-IR, XRD, FE-SEM, HR-TEM, and VSM. Further\\ndemonstrated application of these catalysts for the C-C bond formation reactions of Knoevenagel\\ncondensation employing special aldehyde derivatives with malononitrile at room temperature gave\\nexcellent product isolation.\\n\\n\\n\\nThe application of the prepared functionalized MNPs for the Knoevenagel condensation\\nwas demonstrated by the reaction of various aryl/heterocyclic and cholesterol aldehyde with malononitrile\\nat room temperature stirring for about 30 min in ethanol solvent. The final product isolated\\nis confirmed by various spectroscopic techniques such as FT-IR, 1H-, & 13C-NMR, and mass spectrometry.\\nFurthermore, the selected compounds are screened for their photophysical properties, and\\ninterestingly compound 3j showed good fluorescent properties.\\n\\n\\n\\nOverall the present work described a greener method preparation of MNPs, and its\\nfunctionalized employed as a heterogeneous catalyst for the Knoevenagel condensation of various\\naryl/heterocyclic and cholesterol aldehyde with malononitrile. The method developed is simple,\\neasily separated catalyst by an external magnet, and recycled up to five cycles without any noticeable\\nchange in the final product isolation. Further, the prepared derivatives screened for their photophysical\\nproperties, and interestingly compound 3j showed good fluorescent properties.\\n\",\"PeriodicalId\":10945,\"journal\":{\"name\":\"Current Organocatalysis\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.9000,\"publicationDate\":\"2024-03-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Organocatalysis\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/0122133372292087240228082859\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Organocatalysis","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/0122133372292087240228082859","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Green Method Synthesis of Magnetic Nanoparticles and its Functionalized MNPs for Knoevenagel Condensation Reaction
Knoevenagel condensation is an important C-C bond formation reaction
catalyzed by various homogeneous and heterogeneous acid-base catalysts.
Knoevenagel condensation is an important C-C bond formation reaction, and employs various acid and base-catalyzed reactions of both homogeneous and heterogeneous catalysts.
The present work describes the eco-friendly preparation of magnetic nanoparticles Fe3O4
(MNPs) and its functionalization to Fe3O4@SiO2@SO3H. The prepared MNPs and their functionalized
materials were fully characterized by FT-IR, XRD, FE-SEM, HR-TEM, and VSM. Further
demonstrated application of these catalysts for the C-C bond formation reactions of Knoevenagel
condensation employing special aldehyde derivatives with malononitrile at room temperature gave
excellent product isolation.
The application of the prepared functionalized MNPs for the Knoevenagel condensation
was demonstrated by the reaction of various aryl/heterocyclic and cholesterol aldehyde with malononitrile
at room temperature stirring for about 30 min in ethanol solvent. The final product isolated
is confirmed by various spectroscopic techniques such as FT-IR, 1H-, & 13C-NMR, and mass spectrometry.
Furthermore, the selected compounds are screened for their photophysical properties, and
interestingly compound 3j showed good fluorescent properties.
Overall the present work described a greener method preparation of MNPs, and its
functionalized employed as a heterogeneous catalyst for the Knoevenagel condensation of various
aryl/heterocyclic and cholesterol aldehyde with malononitrile. The method developed is simple,
easily separated catalyst by an external magnet, and recycled up to five cycles without any noticeable
change in the final product isolation. Further, the prepared derivatives screened for their photophysical
properties, and interestingly compound 3j showed good fluorescent properties.
期刊介绍:
Current Organocatalysis is an international peer-reviewed journal that publishes significant research in all areas of organocatalysis. The journal covers organo homogeneous/heterogeneous catalysis, innovative mechanistic studies and kinetics of organocatalytic processes focusing on practical, theoretical and computational aspects. It also includes potential applications of organocatalysts in the fields of drug discovery, synthesis of novel molecules, synthetic method development, green chemistry and chemoenzymatic reactions. This journal also accepts papers on methods, reagents, and mechanism of a synthetic process and technology pertaining to chemistry. Moreover, this journal features full-length/mini review articles within organocatalysis and synthetic chemistry. It is the premier source of organocatalysis and synthetic methods related information for chemists, biologists and engineers pursuing research in industry and academia.