用绿色方法合成用于克诺文纳格尔缩合反应的磁性纳米颗粒及其功能化 MNPs

IF 0.9 Q4 CHEMISTRY, PHYSICAL
Raju Shekhanavar, S. Khatavi, Kantharaju Kamanna
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引用次数: 0

摘要

Knoevenagel 缩合反应是一种重要的 C-C 键形成反应,采用了多种均相和异相酸碱催化剂催化反应。本工作介绍了磁性纳米粒子 Fe3O4(MNPs)的环保制备及其功能化为 Fe3O4@SiO2@SO3H。通过傅立叶变换红外光谱、X 射线衍射、FE-SEM、HR-TEM 和 VSM 对制备的 MNPs 及其功能化材料进行了全面表征。制备的功能化 MNPs 在 Knoevenagel 缩合反应中的应用通过各种芳基/杂环醛和胆固醇醛与丙二腈在乙醇溶剂中室温搅拌约 30 分钟的反应得到证实。此外,还对所选化合物的光物理特性进行了筛选,有趣的是化合物 3j 显示出良好的荧光特性。总之,本研究工作描述了一种更环保的 MNPs 制备方法,并将其功能化用作异相催化剂,用于各种芳基/杂环醛和胆固醇醛与丙二腈的 Knoevenagel 缩合反应。所开发的方法简单,通过外部磁铁即可轻松分离催化剂,并可循环使用五次,最终产品的分离不会发生任何明显变化。此外,还对所制备的衍生物进行了光物理特性筛选,有趣的是化合物 3j 显示出良好的荧光特性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Green Method Synthesis of Magnetic Nanoparticles and its Functionalized MNPs for Knoevenagel Condensation Reaction
Knoevenagel condensation is an important C-C bond formation reaction catalyzed by various homogeneous and heterogeneous acid-base catalysts. Knoevenagel condensation is an important C-C bond formation reaction, and employs various acid and base-catalyzed reactions of both homogeneous and heterogeneous catalysts. The present work describes the eco-friendly preparation of magnetic nanoparticles Fe3O4 (MNPs) and its functionalization to Fe3O4@SiO2@SO3H. The prepared MNPs and their functionalized materials were fully characterized by FT-IR, XRD, FE-SEM, HR-TEM, and VSM. Further demonstrated application of these catalysts for the C-C bond formation reactions of Knoevenagel condensation employing special aldehyde derivatives with malononitrile at room temperature gave excellent product isolation. The application of the prepared functionalized MNPs for the Knoevenagel condensation was demonstrated by the reaction of various aryl/heterocyclic and cholesterol aldehyde with malononitrile at room temperature stirring for about 30 min in ethanol solvent. The final product isolated is confirmed by various spectroscopic techniques such as FT-IR, 1H-, & 13C-NMR, and mass spectrometry. Furthermore, the selected compounds are screened for their photophysical properties, and interestingly compound 3j showed good fluorescent properties. Overall the present work described a greener method preparation of MNPs, and its functionalized employed as a heterogeneous catalyst for the Knoevenagel condensation of various aryl/heterocyclic and cholesterol aldehyde with malononitrile. The method developed is simple, easily separated catalyst by an external magnet, and recycled up to five cycles without any noticeable change in the final product isolation. Further, the prepared derivatives screened for their photophysical properties, and interestingly compound 3j showed good fluorescent properties.
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来源期刊
Current Organocatalysis
Current Organocatalysis CHEMISTRY, PHYSICAL-
CiteScore
2.00
自引率
0.00%
发文量
28
期刊介绍: Current Organocatalysis is an international peer-reviewed journal that publishes significant research in all areas of organocatalysis. The journal covers organo homogeneous/heterogeneous catalysis, innovative mechanistic studies and kinetics of organocatalytic processes focusing on practical, theoretical and computational aspects. It also includes potential applications of organocatalysts in the fields of drug discovery, synthesis of novel molecules, synthetic method development, green chemistry and chemoenzymatic reactions. This journal also accepts papers on methods, reagents, and mechanism of a synthetic process and technology pertaining to chemistry. Moreover, this journal features full-length/mini review articles within organocatalysis and synthetic chemistry. It is the premier source of organocatalysis and synthetic methods related information for chemists, biologists and engineers pursuing research in industry and academia.
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