莪术对砷引起的查尔斯-福斯特大鼠生殖毒性的改善作用

Shazia Naheed Akhter, Rekha Kumari, Arun Kumar
{"title":"莪术对砷引起的查尔斯-福斯特大鼠生殖毒性的改善作用","authors":"Shazia Naheed Akhter, Rekha Kumari, Arun Kumar","doi":"10.53555/jaz.v45i3.3782","DOIUrl":null,"url":null,"abstract":"The present study aims to develop the antidote against arsenic induced male reproductive toxicity in animal models. The study was carried out on Charles Foster Rats after the approval from Institutional Animal Ethics Committee. A total of n=18, rats (12 weeks old) of an average weight of 160 ± 20 g were used for the study. The study group included n=6 control and n= 12 treated with sodium arsenite orally at the dose of 8mg/Kg b.w daily for 40 days. The n= 6 animals were dissected and rest n=6 was administered orally with Curcuma longa rhizome ethanolic extract at the dose of 600mg/Kg b.w per day for 40 days. At the end of the entire experiment, all the animals were dissected out and their reproductive organs were taken out, especially epididymis for sperm counts, sperm motility, sperm mortality, sperm morphology. The blood samples were collected for the hormonal assay (testosterone and luteinizing hormone), as well as for hematological and biochemical analysis. The study showed, high magnitude of degeneration in the reproductive organs of the rats in the arsenic treated group. There were degenerative fluctuations in the sperm counts, sperm motility, sperm mortality, sperm morphology and in the hormonal parameters, as well as in the hematological and biochemical parameters in the arsenic treated rats. But, after the administration of Curcuma longa, there was significant amelioration in all these parameters. Therefore, the present study shows that Curcuma longa plays vital role to combat arsenic induced male reproductive toxicity.","PeriodicalId":509303,"journal":{"name":"Journal of Advanced Zoology","volume":"81 5","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Ameliorative effect of Curcuma longa against arsenic induced reproductive toxicity in Charles Foster rats\",\"authors\":\"Shazia Naheed Akhter, Rekha Kumari, Arun Kumar\",\"doi\":\"10.53555/jaz.v45i3.3782\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The present study aims to develop the antidote against arsenic induced male reproductive toxicity in animal models. The study was carried out on Charles Foster Rats after the approval from Institutional Animal Ethics Committee. A total of n=18, rats (12 weeks old) of an average weight of 160 ± 20 g were used for the study. The study group included n=6 control and n= 12 treated with sodium arsenite orally at the dose of 8mg/Kg b.w daily for 40 days. The n= 6 animals were dissected and rest n=6 was administered orally with Curcuma longa rhizome ethanolic extract at the dose of 600mg/Kg b.w per day for 40 days. At the end of the entire experiment, all the animals were dissected out and their reproductive organs were taken out, especially epididymis for sperm counts, sperm motility, sperm mortality, sperm morphology. The blood samples were collected for the hormonal assay (testosterone and luteinizing hormone), as well as for hematological and biochemical analysis. The study showed, high magnitude of degeneration in the reproductive organs of the rats in the arsenic treated group. There were degenerative fluctuations in the sperm counts, sperm motility, sperm mortality, sperm morphology and in the hormonal parameters, as well as in the hematological and biochemical parameters in the arsenic treated rats. But, after the administration of Curcuma longa, there was significant amelioration in all these parameters. Therefore, the present study shows that Curcuma longa plays vital role to combat arsenic induced male reproductive toxicity.\",\"PeriodicalId\":509303,\"journal\":{\"name\":\"Journal of Advanced Zoology\",\"volume\":\"81 5\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-03-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Advanced Zoology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.53555/jaz.v45i3.3782\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Advanced Zoology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.53555/jaz.v45i3.3782","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

本研究旨在开发针对砷诱导的雄性生殖毒性动物模型的解毒剂。经动物伦理委员会批准,本研究以查尔斯-福斯特大鼠为研究对象。研究共使用了 18 只大鼠(12 周大),平均体重为 160 ± 20 克。研究组包括 n=6 对照组和 n=12 亚砷酸钠治疗组,亚砷酸钠剂量为每天 8 毫克/千克体重,连续 40 天。对 n=6 只动物进行解剖,其余 n=6 只动物按每天 600 毫克/千克体重的剂量口服莪术根茎乙醇提取物,连续 40 天。整个实验结束后,解剖所有动物,取出其生殖器官,尤其是附睾,检测精子数量、精子活力、精子死亡率和精子形态。采集的血液样本用于激素检测(睾酮和黄体生成素)以及血液和生化分析。研究结果表明,砷处理组大鼠的生殖器官退化程度较高。砷处理组大鼠的精子数量、精子活力、精子死亡率、精子形态、激素参数以及血液和生化参数都出现了退化性波动。但在服用姜黄后,所有这些参数都有明显改善。因此,本研究表明,莪术在对抗砷引起的雄性生殖毒性方面发挥着重要作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ameliorative effect of Curcuma longa against arsenic induced reproductive toxicity in Charles Foster rats
The present study aims to develop the antidote against arsenic induced male reproductive toxicity in animal models. The study was carried out on Charles Foster Rats after the approval from Institutional Animal Ethics Committee. A total of n=18, rats (12 weeks old) of an average weight of 160 ± 20 g were used for the study. The study group included n=6 control and n= 12 treated with sodium arsenite orally at the dose of 8mg/Kg b.w daily for 40 days. The n= 6 animals were dissected and rest n=6 was administered orally with Curcuma longa rhizome ethanolic extract at the dose of 600mg/Kg b.w per day for 40 days. At the end of the entire experiment, all the animals were dissected out and their reproductive organs were taken out, especially epididymis for sperm counts, sperm motility, sperm mortality, sperm morphology. The blood samples were collected for the hormonal assay (testosterone and luteinizing hormone), as well as for hematological and biochemical analysis. The study showed, high magnitude of degeneration in the reproductive organs of the rats in the arsenic treated group. There were degenerative fluctuations in the sperm counts, sperm motility, sperm mortality, sperm morphology and in the hormonal parameters, as well as in the hematological and biochemical parameters in the arsenic treated rats. But, after the administration of Curcuma longa, there was significant amelioration in all these parameters. Therefore, the present study shows that Curcuma longa plays vital role to combat arsenic induced male reproductive toxicity.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信