冠心病患者的心房颤动:血小板特征和超声心动图指标

I. Melnychuk
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Platelets amino acids spectrum was detected by method of ion exchange liquid column chromatography. \nResults: II group patients had significantly lower PC (12.20%) and higher MPV (9.30%) and PLR (41.12%) then in I group, P<0.05. II group patients had significantly higher levels of platelets isoleucine (10.73%), leucine (12.63%) and lower threonine (23.05%), serine (5.06%), glycine (32.21%), valine (30.83%) levels then in I group, P<0.05. II group patients had significantly higher levels of left atrium diameter (10.03%), left atrium volume (15.40%) and left atrium volume index (11.48%) then in I group, P <0.05. Left atrium volume and left atrium volume index were corelated with PC (r=-0.315 and r=-0.444 consequently), MPV (r=0.327 and r=0.331 consequently), PLR (r=0.313 and r=0.303 consequently) and platelets serine (r=-0.302 and r=-0.310 consequently), alanine (r=-0.306 and r=-0.355 consequently) and leucine (r=0.346 and r=0.311 consequently), P<0.05. Left ventricular mass and left ventricular mass index were corelated with MPV (r=0.308 and r=0.301 consequently), PLR (r=0.307 and r=0.305 consequently) and platelets arginine (r=0.366 and r=0.305 consequently), threonine (r=-0.474 and r=-0.383 consequently), serine (r=-0.387 and r=-0.361 consequently), alanine (r=-0.342 and r=-0.326 consequently), isoleucine (r=0.355 and r=0.328 consequently) and tyrosine (r=0.307 and r=0.321 consequently), P<0.05. \nConclusions: Left atrium size and left ventricular mass are connected with MPV, PLR and platelets amino acids content: serine, threonine, alanine, leucine, isoleucine and tyrosine levels.","PeriodicalId":502404,"journal":{"name":"Clinical and Preventive Medicine","volume":"19 74","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"ATRIAL FIBRILATION IN CORONARY ARTERY DISEASE PATIENTS: PLATELETS CHARACTERISTICS AND ECHOCARDIOGRAPHY INDEXES\",\"authors\":\"I. 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引用次数: 0

摘要

目的:揭示冠状动脉疾病(CAD)和心房颤动(AF)患者的血小板形态和生化特征与超声心动图(TTE)指标之间的联系。材料和方法:300 名患者分为 3 组:第一组(CAD)--149 名患有 CAD 但无心律失常的患者;第二组(CAD+AF)--124 名患有 CAD 并伴有房颤阵发性发作的患者;对照组--27 名无 CAD 和心律失常的患者。TTE 由 ALOKA SSD-5000 完成。血小板计数(PC)、平均血小板体积(MPV)、血小板分布宽度(PDW)和血小板与白细胞比值(PLR)由普通血细胞计数获得。采用离子交换液柱色谱法检测血小板氨基酸谱。结果显示II 组患者的 PC 值(12.20%)明显低于 I 组,MPV 值(9.30%)和 PLR 值(41.12%)明显高于 I 组,P<0.05。II 组患者的血小板异亮氨酸(10.73%)和亮氨酸(12.63%)水平明显高于 I 组,苏氨酸(23.05%)、丝氨酸(5.06%)、甘氨酸(32.21%)和缬氨酸(30.83%)水平则低于 I 组,P<0.05。II 组患者的左心房直径(10.03%)、左心房容积(15.40%)和左心房容积指数(11.48%)明显高于 I 组,P<0.05。左心房容积和左心房容积指数与 PC(r=-0.315 和 r=-0.444)、MPV(r=0.327 和 r=0.331)、PLR(r=0.313 和 r=0.303 因此)和血小板丝氨酸(r=-0.302 和 r=-0.310 因此)、丙氨酸(r=-0.306 和 r=-0.355 因此)和亮氨酸(r=0.346 和 r=0.311 因此),P<0.05。左心室质量和左心室质量指数与 MPV(r=0.308 和 r=0.301)、PLR(r=0.307 和 r=0.305)和血小板精氨酸(r=0.366 和 r=0.305)、苏氨酸(r=-0.474和r=-0.383)、丝氨酸(r=-0.387和r=-0.361)、丙氨酸(r=-0.342和r=-0.326)、异亮氨酸(r=0.355和r=0.328)和酪氨酸(r=0.307和r=0.321),P<0.05。结论左心房大小和左心室质量与 MPV、PLR 和血小板氨基酸含量(丝氨酸、苏氨酸、丙氨酸、亮氨酸、异亮氨酸和酪氨酸水平)有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
ATRIAL FIBRILATION IN CORONARY ARTERY DISEASE PATIENTS: PLATELETS CHARACTERISTICS AND ECHOCARDIOGRAPHY INDEXES
The aim: To reveal the connections between platelets morphological and biochemical characteristics and echocardiography (TTE) indexes in patients with coronary artery disease (CAD) and atrial fibrillation (AF). Materials and methods: 300 patients were divided into 3 groups: first (CAD) – 149 patients with CAD but without arrhythmias, second (CAD+AF) – 124 patients with CAD and AF paroxysm and control group – 27 patients without CAD and arrhythmias. TTE was done by ALOKA SSD-5000. Platelets count (PC), mean platelet volume (MPV), platelets distribution width (PDW) and platelet-to-leucocyte ratio (PLR) was obtained by common blood count. Platelets amino acids spectrum was detected by method of ion exchange liquid column chromatography. Results: II group patients had significantly lower PC (12.20%) and higher MPV (9.30%) and PLR (41.12%) then in I group, P<0.05. II group patients had significantly higher levels of platelets isoleucine (10.73%), leucine (12.63%) and lower threonine (23.05%), serine (5.06%), glycine (32.21%), valine (30.83%) levels then in I group, P<0.05. II group patients had significantly higher levels of left atrium diameter (10.03%), left atrium volume (15.40%) and left atrium volume index (11.48%) then in I group, P <0.05. Left atrium volume and left atrium volume index were corelated with PC (r=-0.315 and r=-0.444 consequently), MPV (r=0.327 and r=0.331 consequently), PLR (r=0.313 and r=0.303 consequently) and platelets serine (r=-0.302 and r=-0.310 consequently), alanine (r=-0.306 and r=-0.355 consequently) and leucine (r=0.346 and r=0.311 consequently), P<0.05. Left ventricular mass and left ventricular mass index were corelated with MPV (r=0.308 and r=0.301 consequently), PLR (r=0.307 and r=0.305 consequently) and platelets arginine (r=0.366 and r=0.305 consequently), threonine (r=-0.474 and r=-0.383 consequently), serine (r=-0.387 and r=-0.361 consequently), alanine (r=-0.342 and r=-0.326 consequently), isoleucine (r=0.355 and r=0.328 consequently) and tyrosine (r=0.307 and r=0.321 consequently), P<0.05. Conclusions: Left atrium size and left ventricular mass are connected with MPV, PLR and platelets amino acids content: serine, threonine, alanine, leucine, isoleucine and tyrosine levels.
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