{"title":"冠心病患者的心房颤动:血小板特征和超声心动图指标","authors":"I. Melnychuk","doi":"10.31612/2616-4868.1.2024.06","DOIUrl":null,"url":null,"abstract":"The aim: To reveal the connections between platelets morphological and biochemical characteristics and echocardiography (TTE) indexes in patients with coronary artery disease (CAD) and atrial fibrillation (AF). \nMaterials and methods: 300 patients were divided into 3 groups: first (CAD) – 149 patients with CAD but without arrhythmias, second (CAD+AF) – 124 patients with CAD and AF paroxysm and control group – 27 patients without CAD and arrhythmias. TTE was done by ALOKA SSD-5000. Platelets count (PC), mean platelet volume (MPV), platelets distribution width (PDW) and platelet-to-leucocyte ratio (PLR) was obtained by common blood count. Platelets amino acids spectrum was detected by method of ion exchange liquid column chromatography. \nResults: II group patients had significantly lower PC (12.20%) and higher MPV (9.30%) and PLR (41.12%) then in I group, P<0.05. II group patients had significantly higher levels of platelets isoleucine (10.73%), leucine (12.63%) and lower threonine (23.05%), serine (5.06%), glycine (32.21%), valine (30.83%) levels then in I group, P<0.05. II group patients had significantly higher levels of left atrium diameter (10.03%), left atrium volume (15.40%) and left atrium volume index (11.48%) then in I group, P <0.05. Left atrium volume and left atrium volume index were corelated with PC (r=-0.315 and r=-0.444 consequently), MPV (r=0.327 and r=0.331 consequently), PLR (r=0.313 and r=0.303 consequently) and platelets serine (r=-0.302 and r=-0.310 consequently), alanine (r=-0.306 and r=-0.355 consequently) and leucine (r=0.346 and r=0.311 consequently), P<0.05. Left ventricular mass and left ventricular mass index were corelated with MPV (r=0.308 and r=0.301 consequently), PLR (r=0.307 and r=0.305 consequently) and platelets arginine (r=0.366 and r=0.305 consequently), threonine (r=-0.474 and r=-0.383 consequently), serine (r=-0.387 and r=-0.361 consequently), alanine (r=-0.342 and r=-0.326 consequently), isoleucine (r=0.355 and r=0.328 consequently) and tyrosine (r=0.307 and r=0.321 consequently), P<0.05. \nConclusions: Left atrium size and left ventricular mass are connected with MPV, PLR and platelets amino acids content: serine, threonine, alanine, leucine, isoleucine and tyrosine levels.","PeriodicalId":502404,"journal":{"name":"Clinical and Preventive Medicine","volume":"19 74","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"ATRIAL FIBRILATION IN CORONARY ARTERY DISEASE PATIENTS: PLATELETS CHARACTERISTICS AND ECHOCARDIOGRAPHY INDEXES\",\"authors\":\"I. Melnychuk\",\"doi\":\"10.31612/2616-4868.1.2024.06\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The aim: To reveal the connections between platelets morphological and biochemical characteristics and echocardiography (TTE) indexes in patients with coronary artery disease (CAD) and atrial fibrillation (AF). \\nMaterials and methods: 300 patients were divided into 3 groups: first (CAD) – 149 patients with CAD but without arrhythmias, second (CAD+AF) – 124 patients with CAD and AF paroxysm and control group – 27 patients without CAD and arrhythmias. TTE was done by ALOKA SSD-5000. Platelets count (PC), mean platelet volume (MPV), platelets distribution width (PDW) and platelet-to-leucocyte ratio (PLR) was obtained by common blood count. Platelets amino acids spectrum was detected by method of ion exchange liquid column chromatography. \\nResults: II group patients had significantly lower PC (12.20%) and higher MPV (9.30%) and PLR (41.12%) then in I group, P<0.05. II group patients had significantly higher levels of platelets isoleucine (10.73%), leucine (12.63%) and lower threonine (23.05%), serine (5.06%), glycine (32.21%), valine (30.83%) levels then in I group, P<0.05. II group patients had significantly higher levels of left atrium diameter (10.03%), left atrium volume (15.40%) and left atrium volume index (11.48%) then in I group, P <0.05. Left atrium volume and left atrium volume index were corelated with PC (r=-0.315 and r=-0.444 consequently), MPV (r=0.327 and r=0.331 consequently), PLR (r=0.313 and r=0.303 consequently) and platelets serine (r=-0.302 and r=-0.310 consequently), alanine (r=-0.306 and r=-0.355 consequently) and leucine (r=0.346 and r=0.311 consequently), P<0.05. Left ventricular mass and left ventricular mass index were corelated with MPV (r=0.308 and r=0.301 consequently), PLR (r=0.307 and r=0.305 consequently) and platelets arginine (r=0.366 and r=0.305 consequently), threonine (r=-0.474 and r=-0.383 consequently), serine (r=-0.387 and r=-0.361 consequently), alanine (r=-0.342 and r=-0.326 consequently), isoleucine (r=0.355 and r=0.328 consequently) and tyrosine (r=0.307 and r=0.321 consequently), P<0.05. \\nConclusions: Left atrium size and left ventricular mass are connected with MPV, PLR and platelets amino acids content: serine, threonine, alanine, leucine, isoleucine and tyrosine levels.\",\"PeriodicalId\":502404,\"journal\":{\"name\":\"Clinical and Preventive Medicine\",\"volume\":\"19 74\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-03-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical and Preventive Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.31612/2616-4868.1.2024.06\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and Preventive Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31612/2616-4868.1.2024.06","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
ATRIAL FIBRILATION IN CORONARY ARTERY DISEASE PATIENTS: PLATELETS CHARACTERISTICS AND ECHOCARDIOGRAPHY INDEXES
The aim: To reveal the connections between platelets morphological and biochemical characteristics and echocardiography (TTE) indexes in patients with coronary artery disease (CAD) and atrial fibrillation (AF).
Materials and methods: 300 patients were divided into 3 groups: first (CAD) – 149 patients with CAD but without arrhythmias, second (CAD+AF) – 124 patients with CAD and AF paroxysm and control group – 27 patients without CAD and arrhythmias. TTE was done by ALOKA SSD-5000. Platelets count (PC), mean platelet volume (MPV), platelets distribution width (PDW) and platelet-to-leucocyte ratio (PLR) was obtained by common blood count. Platelets amino acids spectrum was detected by method of ion exchange liquid column chromatography.
Results: II group patients had significantly lower PC (12.20%) and higher MPV (9.30%) and PLR (41.12%) then in I group, P<0.05. II group patients had significantly higher levels of platelets isoleucine (10.73%), leucine (12.63%) and lower threonine (23.05%), serine (5.06%), glycine (32.21%), valine (30.83%) levels then in I group, P<0.05. II group patients had significantly higher levels of left atrium diameter (10.03%), left atrium volume (15.40%) and left atrium volume index (11.48%) then in I group, P <0.05. Left atrium volume and left atrium volume index were corelated with PC (r=-0.315 and r=-0.444 consequently), MPV (r=0.327 and r=0.331 consequently), PLR (r=0.313 and r=0.303 consequently) and platelets serine (r=-0.302 and r=-0.310 consequently), alanine (r=-0.306 and r=-0.355 consequently) and leucine (r=0.346 and r=0.311 consequently), P<0.05. Left ventricular mass and left ventricular mass index were corelated with MPV (r=0.308 and r=0.301 consequently), PLR (r=0.307 and r=0.305 consequently) and platelets arginine (r=0.366 and r=0.305 consequently), threonine (r=-0.474 and r=-0.383 consequently), serine (r=-0.387 and r=-0.361 consequently), alanine (r=-0.342 and r=-0.326 consequently), isoleucine (r=0.355 and r=0.328 consequently) and tyrosine (r=0.307 and r=0.321 consequently), P<0.05.
Conclusions: Left atrium size and left ventricular mass are connected with MPV, PLR and platelets amino acids content: serine, threonine, alanine, leucine, isoleucine and tyrosine levels.