高钙血症伴发慢性肾病,肌肉注射油溶液后出现肾炎

G. Runova, E. Pesheva, A. A. Vastistova, L. Rozhinskaya, I. Poluboyarinova, M. P. Vasilevskaya, O. Gurova, V. Fadeev
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引用次数: 0

摘要

导致 PTH 依赖性高钙血症的罕见原因之一可能是蛋白同化油溶液,健美运动员肌肉注射蛋白同化油溶液和蛋白同化激素,以使肌肉更加突出。下面是一位 43 岁患者的临床报告,他在 25-30 岁时使用过合成代谢油溶液。他患有长期未确诊的高钙血症,表现为肾结石和慢性肾病(CKD)进展。37 岁时首次诊断出高钙血症,但被漏诊。2023 年(43 岁),实验室结果显示血钙水平极高(4.26 毫摩尔/升),PTH 下降,CKD C4。排除了恶性高钙血症的可能。本病例证实了高钙血症的罕见病因--肌肉注射油导致肾炎、肾钙化和 CKD。使用糖皮质激素治疗取得了积极的效果,与肉芽肿性疾病和高钙血症的治疗效果相似。目前正在讨论 PTH 依赖性高钙血症的发病机制和鉴别诊断。本临床病例是一种罕见的高钙血症病因,对各科医生(内分泌科医生、治疗师、泌尿科医生、皮肤科医生等)均有帮助。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hypercalcemia with the development of chronic kidney disease, nephrolithiasis after intramuscular injection of oil solutions
One of the rare causes of PTH-independent hypercalcemia can be anabolic oil solution, injected intramuscularly by bodybuilders, along with anabolic hormones, in order to make the muscles more prominent. Here is the clinical report of a 43-year-old patient who used Synthol oil solution at the age of 25–30 years is presented. He had long-term undiagnosed hypercalcemia that manifested with nephrolithiasis and progressing chronic kidney disease (CKD). For the first time hypercalcemia was diagnosed at the age of 37, but left omitted. In 2023 (43 years) the laboratory findings sowed extremely high calcium level (4.26 mmol/l) with decreased PTH and CKD C4. Malignancy hypercalcemia was excluded. With this case, the rare cause of hypercalcemia has been proven – intramuscular oil injection resulting in nephrolithiasis, nephrocalcinosis and CKD. Treatment with glucocorticoids has demonstrated positive effect, similar to the ones of granulomatous diseases and hypercalcemia. The mechanisms of PTH-independent hypercalcemia development and differential diagnosis are currently being discussed. The presented clinical case of a rare cause of hypercalcemia may be useful for doctors of various specialties: endocrinologists, therapists, urologists, dermatologists, etc.
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