Chelsea A. Crossley, Tamunotonye Omoluabi, Sarah E. Torraville, Sarah Duraid, Aida Maziar, Zia Hasan, Vishaal Rajani, K. Ando, Johannes W Hell, Qi Yuan
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引用次数: 0
摘要
衰老和阿尔茨海默病与神经元通过 L 型钙通道流入的钙长期升高有关。海马是大脑中主要的记忆编码结构，在阿尔茨海默病中更容易受到钙失调的影响。最近的研究表明，L 型钙通道与 tau 过度磷酸化之间存在联系。然而，L 型钙通道介导的 tau 毒性的确切机制尚不清楚。
Hippocampal hyperphosphorylated tau-induced deficiency is rescued by L-type calcium channel blockade
Aging and Alzheimer’s disease are associated with chronic elevations in neuronal calcium influx via L-type calcium channels. The hippocampus, a primary memory encoding structure in the brain, is more vulnerable to calcium dysregulation in Alzheimer’s disease. Recent research has suggested a link between L-type calcium channels and tau hyperphosphorylation. However, the precise mechanism of L-type calcium channel-mediated tau toxicity is not understood.
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