{"title":"2,6-二芳基哌啶酮-y-衍生物的合成及生物活性研究","authors":"K. Hamak, F. Kandil, S. Hamo","doi":"10.24996/iraqijournalofscience.v53i3.12732","DOIUrl":null,"url":null,"abstract":"In the present study new series of2,6-diarylpiperidones-4 derivative were synthesized and these compounds are :1-(1-oxo-2-chloro-ethyl)-3,3-dimethyl-2.6-diarylpiperidone-4(I)1-(1-oxo-2-chloro-ethyl)-3.5-dimethyl-2,6-diarylpiperidone-4(II)1-(1-oxo-2-imidazolyl-ethyl) -3,3-dimethyl-2,6-diphenyl piperidoe-4(III)1-(1-oxo-2-imidazolyl-ethyl)-3,5-dimethyl-2,6-diphenylpiperidoe-4 (IV)The prepared compounds were characterized by IR,LC-MS and 1H,13C-NMR spectra .All compounds were screened for their antibacterial activity against gram positive bacteria :Bacillus subtilis and gram negative bacteria :Escherichia coli at different concentration (1000, 500, 250, 100) ppm. These compounds show good activity against gram positive more than gram negative bacteria","PeriodicalId":14698,"journal":{"name":"Iraqi Journal of Science","volume":"38 s172","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"SYNTHESIS AND STUDY OF BIOLOGICAL ACTIVITIES OF2,6-DIARYLPIPERIDONE –y-DERIVATIVES\",\"authors\":\"K. Hamak, F. Kandil, S. Hamo\",\"doi\":\"10.24996/iraqijournalofscience.v53i3.12732\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In the present study new series of2,6-diarylpiperidones-4 derivative were synthesized and these compounds are :1-(1-oxo-2-chloro-ethyl)-3,3-dimethyl-2.6-diarylpiperidone-4(I)1-(1-oxo-2-chloro-ethyl)-3.5-dimethyl-2,6-diarylpiperidone-4(II)1-(1-oxo-2-imidazolyl-ethyl) -3,3-dimethyl-2,6-diphenyl piperidoe-4(III)1-(1-oxo-2-imidazolyl-ethyl)-3,5-dimethyl-2,6-diphenylpiperidoe-4 (IV)The prepared compounds were characterized by IR,LC-MS and 1H,13C-NMR spectra .All compounds were screened for their antibacterial activity against gram positive bacteria :Bacillus subtilis and gram negative bacteria :Escherichia coli at different concentration (1000, 500, 250, 100) ppm. These compounds show good activity against gram positive more than gram negative bacteria\",\"PeriodicalId\":14698,\"journal\":{\"name\":\"Iraqi Journal of Science\",\"volume\":\"38 s172\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-03-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Iraqi Journal of Science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.24996/iraqijournalofscience.v53i3.12732\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Earth and Planetary Sciences\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iraqi Journal of Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.24996/iraqijournalofscience.v53i3.12732","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Earth and Planetary Sciences","Score":null,"Total":0}
SYNTHESIS AND STUDY OF BIOLOGICAL ACTIVITIES OF2,6-DIARYLPIPERIDONE –y-DERIVATIVES
In the present study new series of2,6-diarylpiperidones-4 derivative were synthesized and these compounds are :1-(1-oxo-2-chloro-ethyl)-3,3-dimethyl-2.6-diarylpiperidone-4(I)1-(1-oxo-2-chloro-ethyl)-3.5-dimethyl-2,6-diarylpiperidone-4(II)1-(1-oxo-2-imidazolyl-ethyl) -3,3-dimethyl-2,6-diphenyl piperidoe-4(III)1-(1-oxo-2-imidazolyl-ethyl)-3,5-dimethyl-2,6-diphenylpiperidoe-4 (IV)The prepared compounds were characterized by IR,LC-MS and 1H,13C-NMR spectra .All compounds were screened for their antibacterial activity against gram positive bacteria :Bacillus subtilis and gram negative bacteria :Escherichia coli at different concentration (1000, 500, 250, 100) ppm. These compounds show good activity against gram positive more than gram negative bacteria
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