再照射联合贝伐单抗治疗胶质母细胞瘤复发

Q4 Medicine
S. V. Belokon, I. Gulidov, D. Gogolin, K. E. Medvedeva, S. A. Ivanov, A. Kaprin
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引用次数: 0

摘要

背景。胶质母细胞瘤(GB)是一种侵袭性疾病,预后较差。尽管对原发疾病采取了综合治疗方法,但复发几乎不可避免。目前仍没有针对胶质母细胞瘤复发的标准治疗方法,许多指南都建议在临床试验中对这些患者进行治疗。目前有多种治疗方案可供选择。其中包括手术、放射治疗、全身或区域化疗或靶向治疗、各种免疫治疗策略、中低频电场及其组合。再照射和全身靶向治疗这两种非侵入性技术的组合仍是这类患者最常用的方法,但其潜力尚未得到充分发挥。本研究的目的是分析将再照射与贝伐珠单抗联合使用作为 GB 患者治疗方案的文献数据。材料与方法。使用 Medline、Cochrane Library、E-library、Scopus、PubMed 和 Google Scholar 数据库进行文献检索。结果。确定了问题的现状,总结并分析了迄今为止使用重复放疗联合竞争性和/或辅助贝伐珠单抗治疗 GB 复发的数据,比较了该方法的不同方案,并描述了该治疗方案的前景和解决现有问题的可能方法。结论再次放疗同时应用贝伐珠单抗可为包括大体积胶质母细胞瘤在内的GB复发提供更安全的治疗,且毒性(尤其是放射性坏死)可接受,特别是在采用适当的分次治疗方案时。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Re-irradiation combined with bevacizumab in the treatment of glioblastoma recurrence
Background. Glioblastoma (GB) remains an aggressive disease with a poor prognosis. despite a comprehensive approach to the treatment of the primary disease, recurrence is almost inevitable. There is still no standard of care for GB recurrence, and many guidelines recommend treating these patients within clinical trials. There are various treatment options available. They include surgery, radiation therapy, systemic or regional chemotherapy or targeted therapy, various immunotherapy strategies, low- and medium-frequency electric fields, and their combinations. The combination of two non-invasive techniques: re-irradiation and systemic targeted therapy remains the most commonly used approach in this group of patients, the potential of which has not been fully realized. The aim of the study was to analyze the literature data on the use of the combination of re-irradiation with bevacizumab as a therapeutic option in patients with GB. Material and Methods. Literature search was performed using Medline, Cochrane Library, E-library, Scopus, PubMed and Google Scholar databases. Results. The current state of the problem was determined, the data available to date on the use of repeated radiotherapy with competitive and/or adjuvant bevacizumab in the treatment of GB recurrence were summarized and analyzed, different regimens of this approach were compared, and the prospects and possible ways of solving the existing problems of this therapeutic option were described. Conclusion. Re-irradiation with concomitant administration of bevacizumab may provide safer treatment of GB recurrence, including large-volume glioblastoma, with acceptable toxicity, in particular radiation necrosis, especially when an appropriate fractionation schedule is used.
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来源期刊
Siberian journal of oncology
Siberian journal of oncology Medicine-Oncology
CiteScore
0.40
自引率
0.00%
发文量
117
审稿时长
8 weeks
期刊介绍: The main objectives of the journal are: -to promote the establishment of Russia’s leading worldwide positions in the field of experimental and clinical oncology- to create the international discussion platform intended to cover all aspects of basic and clinical cancer research, including carcinogenesis, molecular biology, epidemiology, cancer prevention, diagnosis and multimodality treatment (surgery, chemotherapy, radiation therapy, hormone therapy), anesthetic management, medical and social rehabilitation, palliative care as well as the improvement of life quality of cancer patients- to encourage promising young scientists to be actively involved in cancer research programs- to provide a platform for researches and doctors all over the world to promote, share, and discuss various new issues and developments in cancer related problems. (to create a communication platform for the expansion of cooperation between Russian and foreign professional associations).- to provide the information about the latest worldwide achievements in different fields of oncology The most important tasks of the journal are: -to encourage scientists to publish their research results- to offer a forum for active discussion on topics of major interest - to invite the most prominent Russian and foreign authors to share their latest research findings with cancer research community- to promote the exchange of research information, clinical experience, current trends and the recent developments in the field of oncology as well as to review interesting cases encountered by colleagues all over the world- to expand the editorial board and reviewers with the involvement of well-known Russian and foreign experts- to provide open access to full text articles- to include the journal into the international database- to increase the journal’s impact factor- to promote the journal to the International and Russian markets
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