胰腺改良梅奥评分在预测溃疡性结肠炎长期疗效方面的准确性:一种前景看好的评分系统。

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC
ACS Applied Electronic Materials Pub Date : 2024-03-21 eCollection Date: 2024-01-01 DOI:10.1177/17562848241239606
Péter Bacsur, Panu Wetwittayakhlang, Tamás Resál, Emese Földi, Béla Vasas, Bernadett Farkas, Mariann Rutka, Talat Bessissow, Waqqas Afif, Anita Bálint, Anna Fábián, Renáta Bor, Zoltán Szepes, Klaudia Farkas, Peter L Lakatos, Tamás Molnár
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引用次数: 0

摘要

背景:目前有不同的内镜评分系统用于评估溃疡性结肠炎(UC)的严重程度。目的:我们的研究旨在比较 PanMay 评分与内镜下梅奥(Mayo)评分对溃疡性结肠炎(UC)严重程度的预测价值:我们的研究旨在比较 PanMay 评分与内镜下梅奥评分(MES)、溃疡性结肠炎内镜下严重程度指数(UCEIS)和都柏林评分在预测 UC 长期预后方面的预测价值:这项回顾性研究纳入了至少随访 3 年之前接受过结肠镜检查的连续 UC 患者:方法:评估参与者的 PanMayo、MES、UCEIS 和 Dublin 评分以及基线临床和人口统计学特征。终点是需要新型生物疗法、结肠切除术和住院治疗的疾病复发。根据基线临床活动对患者进行分层:结果:在 250 名入选患者中,约 62.8% 的患者临床症状得到缓解。在这些患者中,PanMayo、MES 和都柏林评分与临床复发风险呈正相关。MES 评分随着临床复发而增加。PanMayo 评分(>12 分)而非 MES 评分与是否需要开始使用新型生物制剂和生物制剂升级有关。此外,需要新型生物治疗的缓解期患者的都柏林和 UCEIS 评分也有类似的趋势。结肠切除术的风险与 PanMayo 和都柏林评分有关:结论:对疾病范围和严重程度进行综合内镜评估可更准确地预测 UC 患者的预后。除了现有的评分系统外,还可以使用 PanMayo 评分,从而获得更准确的检查结果。我们的研究旨在分析 PanMayo 评分的预测价值。基于 250 名患者的研究结果显示,PanMayo 评分能更准确地预测 UC 的长期疾病预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Accuracy of the Pancolonic Modified Mayo Score in predicting the long-term outcomes of ulcerative colitis: a promising scoring system.

Background: Different endoscopic scoring systems for assessing ulcerative colitis (UC) severity are available. However, most of them are not correlated with disease extent.

Objectives: Our study aimed to compare the predictive value of the PanMay score versus the endoscopic Mayo (MES), Ulcerative Colitis Endoscopic Index of Severity (UCEIS), and Dublin score in predicting long-term outcomes of UC.

Design: This retrospective study enrolled consecutive UC patients who underwent colonoscopy before at least a 3-year follow-up.

Methods: The PanMayo, MES, UCEIS, and Dublin scores and the baseline clinical and demographic characteristics of the participants were assessed. Endpoints were disease flare that required novel biological therapy, colectomy, and hospitalization. Patients were stratified using baseline clinical activity.

Results: Approximately 62.8% of the 250 enrolled patients were in clinical remission. In these patients, the PanMayo, MES, and Dublin scores were positively associated with the risk of clinical flare. The MES score increased with clinical flare. The PanMayo score (>12 points), but not the MES score, was associated with the need for novel biological initiation and biological escalation. Furthermore, the Dublin and UCEIS scores of patients in remission who need novel biological treatment had a similar trend. Colectomy risk was associated with PanMayo and Dublin scores.

Conclusion: The combined endoscopic assessment of disease extent and severity can be more accurate in predicting outcomes among patients with UC. PanMayo score can be utilized in addition to the existing scoring systems, thereby leading to a more accurate examination.

Summary: UC endoscopic scores do not assess extension. Our study aimed to analyze the predictive value of the PanMayo score. Based on 250 patients, results showed that the long-term disease outcomes of UC could be predicted with the PanMayo score more accurately.

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