同工酶和细胞状态特异性 APOE 平衡与功能。

IF 5.9 2区医学 Q2 CELL BIOLOGY

Neural Regeneration Research Pub Date : 2024-11-01 Epub Date: 2024-01-31 DOI:10.4103/NRR.NRR-D-23-01470

Karina Lindner, Anne-Claude Gavin

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引用次数: 0

摘要

载脂蛋白 E 是大脑中的主要脂质转运体，也是神经元-胃囊代谢耦合中的重要角色。它通过滋养和解毒神经元，确保神经元在应激条件和过度活跃的情况下存活。载脂蛋白 E 的多态性，加上环境压力和/或与年龄有关的改变，会影响晚发性阿尔茨海默病的发病风险。在这篇综述中，我们将讨论脂蛋白 E 的合成、分泌、降解和脂化等脂蛋白 E 平衡状态如何影响阿尔茨海默病的现有知识。

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Isoform- and cell-state-specific APOE homeostasis and function.

Apolipoprotein E is the major lipid transporter in the brain and an important player in neuron-astrocyte metabolic coupling. It ensures the survival of neurons under stressful conditions and hyperactivity by nourishing and detoxifying them. Apolipoprotein E polymorphism, combined with environmental stresses and/or age-related alterations, influences the risk of developing late-onset Alzheimer's disease. In this review, we discuss our current knowledge of how apolipoprotein E homeostasis, i.e. its synthesis, secretion, degradation, and lipidation, is affected in Alzheimer's disease.

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来源期刊

Neural Regeneration Research CELL BIOLOGY-NEUROSCIENCES

CiteScore

8.00

自引率

9.80%

发文量

515

审稿时长

1.0 months

期刊介绍： Neural Regeneration Research (NRR) is the Open Access journal specializing in neural regeneration and indexed by SCI-E and PubMed. The journal is committed to publishing articles on basic pathobiology of injury, repair and protection to the nervous system, while considering preclinical and clinical trials targeted at improving traumatically injuried patients and patients with neurodegenerative diseases.