Veronica Mollica , Francesco Massari , Marco Maruzzo , Davide Bimbatti , Melanie Claps , Brigida Anna Maiorano , Maria Giuseppa Vitale , Roberto Iacovelli , Paola Ermacora , Giandomenico Roviello , Fabio Calabrò , Orazio Caffo , Francesca Vignani , Francesco Grillone , Francesco Pierantoni , Marilena Di Napoli , Alessia Mennitto , Andrea Marchetti , Alvise Mattana , Alessia Cavo , Sebastiano Buti
{"title":"阴茎癌患者的临床结果和预后因素：Meet-URO 23 (I-RARE) 登记研究的子分析。","authors":"Veronica Mollica , Francesco Massari , Marco Maruzzo , Davide Bimbatti , Melanie Claps , Brigida Anna Maiorano , Maria Giuseppa Vitale , Roberto Iacovelli , Paola Ermacora , Giandomenico Roviello , Fabio Calabrò , Orazio Caffo , Francesca Vignani , Francesco Grillone , Francesco Pierantoni , Marilena Di Napoli , Alessia Mennitto , Andrea Marchetti , Alvise Mattana , Alessia Cavo , Sebastiano Buti","doi":"10.1016/j.clgc.2024.102074","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>Penile squamous cell carcinoma (PSCC) is a rare tumor with an aggressive behavior. The Meet-URO 23/I-RARE registry includes rare genitourinary malignancies. We extracted patients with PSCC to conduct a retrospective study aimed at assessing clinical outcomes and prognostic factors.</p></div><div><h3>Patients and Methods</h3><p>Primary endpoints were overall survival and progression-free survival. Prognostic factors for OS and PFS were analyzed using univariate and multivariate analysis.</p><p>From the Meet-URO 23/I-RARE database, we extracted 128 patients with diagnosis of PSCC. About 48% of patients underwent first-line of therapy.</p></div><div><h3>Results</h3><p>In the overall population, median OS from diagnosis was 34.6 months. Significant differences in median OS were observed according to ECOG PS at diagnosis (57.3 months <em>vs.</em> 8.3 months; <em>P</em> < .001), and median age (≤77y 88.8 months <em>vs.</em> >77y 26 months; <em>P</em> = .013). At multivariate analysis, ECOG PS 2-4 at diagnosis (HR 3.04) and lymph node metastases (HR 2.49) were independently associated with a higher risk of death.</p><p>Among patients undergoing first-line therapy (n = 61), median OS was 12.3 months, and a statistically significant difference was found according to type of response to first-line (DCR 24.4 months <em>vs.</em> PD 7.1 months; <em>P</em> < .001). Multivariate analysis showed that only age >77 years was associated with a worse OS (HR 2.16). A statistically significant difference in PFS was found according to platinum plus 5-fluorouracil <em>versus</em> platinum plus taxane (4.9 <em>vs.</em> 3.4 months; <em>P</em> = .036) and regimens with 2 <em>versus</em> 3 drugs (3.4 <em>vs.</em> 8.6 months; <em>P</em> = .019). At the multivariate analysis only regimens with platinum plus taxane were associated with worse PFS (HR 2.83).</p></div><div><h3>Conclusion</h3><p>In our registry study, PSCC is confirmed to be an aggressive disease. Poor ECOG PS, presence of lymph node metastases, and higher age at diagnosis appear to be associated with worse survival outcomes.</p></div>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Clinical Outcomes and Prognostic Factors in Patients With Penile Carcinoma: A Sub-Analysis From Meet-URO 23 (I-RARE) Registry Study\",\"authors\":\"Veronica Mollica , Francesco Massari , Marco Maruzzo , Davide Bimbatti , Melanie Claps , Brigida Anna Maiorano , Maria Giuseppa Vitale , Roberto Iacovelli , Paola Ermacora , Giandomenico Roviello , Fabio Calabrò , Orazio Caffo , Francesca Vignani , Francesco Grillone , Francesco Pierantoni , Marilena Di Napoli , Alessia Mennitto , Andrea Marchetti , Alvise Mattana , Alessia Cavo , Sebastiano Buti\",\"doi\":\"10.1016/j.clgc.2024.102074\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><p>Penile squamous cell carcinoma (PSCC) is a rare tumor with an aggressive behavior. The Meet-URO 23/I-RARE registry includes rare genitourinary malignancies. We extracted patients with PSCC to conduct a retrospective study aimed at assessing clinical outcomes and prognostic factors.</p></div><div><h3>Patients and Methods</h3><p>Primary endpoints were overall survival and progression-free survival. Prognostic factors for OS and PFS were analyzed using univariate and multivariate analysis.</p><p>From the Meet-URO 23/I-RARE database, we extracted 128 patients with diagnosis of PSCC. About 48% of patients underwent first-line of therapy.</p></div><div><h3>Results</h3><p>In the overall population, median OS from diagnosis was 34.6 months. Significant differences in median OS were observed according to ECOG PS at diagnosis (57.3 months <em>vs.</em> 8.3 months; <em>P</em> < .001), and median age (≤77y 88.8 months <em>vs.</em> >77y 26 months; <em>P</em> = .013). At multivariate analysis, ECOG PS 2-4 at diagnosis (HR 3.04) and lymph node metastases (HR 2.49) were independently associated with a higher risk of death.</p><p>Among patients undergoing first-line therapy (n = 61), median OS was 12.3 months, and a statistically significant difference was found according to type of response to first-line (DCR 24.4 months <em>vs.</em> PD 7.1 months; <em>P</em> < .001). Multivariate analysis showed that only age >77 years was associated with a worse OS (HR 2.16). A statistically significant difference in PFS was found according to platinum plus 5-fluorouracil <em>versus</em> platinum plus taxane (4.9 <em>vs.</em> 3.4 months; <em>P</em> = .036) and regimens with 2 <em>versus</em> 3 drugs (3.4 <em>vs.</em> 8.6 months; <em>P</em> = .019). At the multivariate analysis only regimens with platinum plus taxane were associated with worse PFS (HR 2.83).</p></div><div><h3>Conclusion</h3><p>In our registry study, PSCC is confirmed to be an aggressive disease. Poor ECOG PS, presence of lymph node metastases, and higher age at diagnosis appear to be associated with worse survival outcomes.</p></div>\",\"PeriodicalId\":2,\"journal\":{\"name\":\"ACS Applied Bio Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2024-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Bio Materials\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1558767324000454\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1558767324000454","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
Clinical Outcomes and Prognostic Factors in Patients With Penile Carcinoma: A Sub-Analysis From Meet-URO 23 (I-RARE) Registry Study
Introduction
Penile squamous cell carcinoma (PSCC) is a rare tumor with an aggressive behavior. The Meet-URO 23/I-RARE registry includes rare genitourinary malignancies. We extracted patients with PSCC to conduct a retrospective study aimed at assessing clinical outcomes and prognostic factors.
Patients and Methods
Primary endpoints were overall survival and progression-free survival. Prognostic factors for OS and PFS were analyzed using univariate and multivariate analysis.
From the Meet-URO 23/I-RARE database, we extracted 128 patients with diagnosis of PSCC. About 48% of patients underwent first-line of therapy.
Results
In the overall population, median OS from diagnosis was 34.6 months. Significant differences in median OS were observed according to ECOG PS at diagnosis (57.3 months vs. 8.3 months; P < .001), and median age (≤77y 88.8 months vs. >77y 26 months; P = .013). At multivariate analysis, ECOG PS 2-4 at diagnosis (HR 3.04) and lymph node metastases (HR 2.49) were independently associated with a higher risk of death.
Among patients undergoing first-line therapy (n = 61), median OS was 12.3 months, and a statistically significant difference was found according to type of response to first-line (DCR 24.4 months vs. PD 7.1 months; P < .001). Multivariate analysis showed that only age >77 years was associated with a worse OS (HR 2.16). A statistically significant difference in PFS was found according to platinum plus 5-fluorouracil versus platinum plus taxane (4.9 vs. 3.4 months; P = .036) and regimens with 2 versus 3 drugs (3.4 vs. 8.6 months; P = .019). At the multivariate analysis only regimens with platinum plus taxane were associated with worse PFS (HR 2.83).
Conclusion
In our registry study, PSCC is confirmed to be an aggressive disease. Poor ECOG PS, presence of lymph node metastases, and higher age at diagnosis appear to be associated with worse survival outcomes.
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