Shengquan Wang , Lei Sun , Hongxia Gao , Wenpei Zhang
{"title":"博莱霉素金属有机框架水凝胶对血管瘤的治疗活性","authors":"Shengquan Wang , Lei Sun , Hongxia Gao , Wenpei Zhang","doi":"10.1016/j.ica.2024.122009","DOIUrl":null,"url":null,"abstract":"<div><p>In the current paper, through utilizing two symmetrical pentacarboxylate ligands, namely, 3,5-di(2′,5′-dicarboxylphenyl)benzoic (H<sub>5</sub>L<sub>1</sub>) and 3,5-di(2′,4′ dicarboxylphenyl)benzoic acid (H<sub>5</sub>L<sub>2</sub>), two fresh Co(II)-basd coordination polymers (CPs), [Co<sub>5</sub>(μ<sub>3</sub>-H<sub>2</sub>O)<sub>2</sub>(L1)<sub>2</sub>]·3DMA·4H<sub>2</sub>O (<strong>1</strong>, DMA is N,<em>N</em>-dimethylacetamide) along with [Co<sub>3</sub>(μ<sub>3</sub>-OH)L2(H<sub>2</sub>O)<sub>3</sub>]·H<sub>2</sub>O (<strong>2</strong>) have been synthesized under the conditions of solvothermal. With hyaluronic acid (HA) and carboxymethyl chitosan (CMCS) as raw materials, HA/CMCS hydrogel was prepared by chemical synthesis and its internal microstructure was observed by scanning electron microscope. Using bleomycin as a drug model, we designed and synthesized two metallogel particle frameworks encapsulating bleomycin drugs and compared the effects of the two metallogel particle frameworks as drug carriers for delivering bleomycin drugs for the treatment of hemangiomas.</p></div>","PeriodicalId":13599,"journal":{"name":"Inorganica Chimica Acta","volume":"566 ","pages":"Article 122009"},"PeriodicalIF":2.7000,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Treatment activity of hydrogels loaded with metal–organic frameworks of bleomycin on hemangioma\",\"authors\":\"Shengquan Wang , Lei Sun , Hongxia Gao , Wenpei Zhang\",\"doi\":\"10.1016/j.ica.2024.122009\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In the current paper, through utilizing two symmetrical pentacarboxylate ligands, namely, 3,5-di(2′,5′-dicarboxylphenyl)benzoic (H<sub>5</sub>L<sub>1</sub>) and 3,5-di(2′,4′ dicarboxylphenyl)benzoic acid (H<sub>5</sub>L<sub>2</sub>), two fresh Co(II)-basd coordination polymers (CPs), [Co<sub>5</sub>(μ<sub>3</sub>-H<sub>2</sub>O)<sub>2</sub>(L1)<sub>2</sub>]·3DMA·4H<sub>2</sub>O (<strong>1</strong>, DMA is N,<em>N</em>-dimethylacetamide) along with [Co<sub>3</sub>(μ<sub>3</sub>-OH)L2(H<sub>2</sub>O)<sub>3</sub>]·H<sub>2</sub>O (<strong>2</strong>) have been synthesized under the conditions of solvothermal. With hyaluronic acid (HA) and carboxymethyl chitosan (CMCS) as raw materials, HA/CMCS hydrogel was prepared by chemical synthesis and its internal microstructure was observed by scanning electron microscope. Using bleomycin as a drug model, we designed and synthesized two metallogel particle frameworks encapsulating bleomycin drugs and compared the effects of the two metallogel particle frameworks as drug carriers for delivering bleomycin drugs for the treatment of hemangiomas.</p></div>\",\"PeriodicalId\":13599,\"journal\":{\"name\":\"Inorganica Chimica Acta\",\"volume\":\"566 \",\"pages\":\"Article 122009\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2024-03-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Inorganica Chimica Acta\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0020169324000999\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Inorganica Chimica Acta","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0020169324000999","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
Treatment activity of hydrogels loaded with metal–organic frameworks of bleomycin on hemangioma
In the current paper, through utilizing two symmetrical pentacarboxylate ligands, namely, 3,5-di(2′,5′-dicarboxylphenyl)benzoic (H5L1) and 3,5-di(2′,4′ dicarboxylphenyl)benzoic acid (H5L2), two fresh Co(II)-basd coordination polymers (CPs), [Co5(μ3-H2O)2(L1)2]·3DMA·4H2O (1, DMA is N,N-dimethylacetamide) along with [Co3(μ3-OH)L2(H2O)3]·H2O (2) have been synthesized under the conditions of solvothermal. With hyaluronic acid (HA) and carboxymethyl chitosan (CMCS) as raw materials, HA/CMCS hydrogel was prepared by chemical synthesis and its internal microstructure was observed by scanning electron microscope. Using bleomycin as a drug model, we designed and synthesized two metallogel particle frameworks encapsulating bleomycin drugs and compared the effects of the two metallogel particle frameworks as drug carriers for delivering bleomycin drugs for the treatment of hemangiomas.
期刊介绍：
Inorganica Chimica Acta is an established international forum for all aspects of advanced Inorganic Chemistry. Original papers of high scientific level and interest are published in the form of Articles and Reviews.
Topics covered include:
• chemistry of the main group elements and the d- and f-block metals, including the synthesis, characterization and reactivity of coordination, organometallic, biomimetic, supramolecular coordination compounds, including associated computational studies;
• synthesis, physico-chemical properties, applications of molecule-based nano-scaled clusters and nanomaterials designed using the principles of coordination chemistry, as well as coordination polymers (CPs), metal-organic frameworks (MOFs), metal-organic polyhedra (MPOs);
• reaction mechanisms and physico-chemical investigations computational studies of metalloenzymes and their models;
• applications of inorganic compounds, metallodrugs and molecule-based materials.
Papers composed primarily of structural reports will typically not be considered for publication.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
